Stanley Appel, MD
Enriched profilePeggy and Gary Edwards Distinguished Chair for ALS Research; Chair, Stanley H. Appel Department of Neurology; Co-Director, Houston Methodist Neurological Institute; Director, MDA/ALSA ALS Research Clinical Center; Director, Ann Kimball and John W. Johnson Center for Cellular Therapeutics · Houston Methodist Academic Institute
Stanley Appel is Peggy and Gary Edwards Distinguished Chair for ALS Research; Chair, Stanley H. Appel Department of Neurology; Co-Director, Houston Methodist Neurological Institute; Director, MDA/ALSA ALS Research Clinical Center; Director, Ann Kimball and John W. Johnson Center for Cellular Therapeutics at Houston Methodist Academic Institute. OpenAlex indexes 507 publications with 37,192 citations (h-index 101); ClinicalTrials.gov lists 2 registered studies with this person as an investigator. By OpenAlex citation count, this profile ranks in the top 5% of Neurology profiles in the findmyKOL directory.
Data verified 14 Aug 2026
Overview
Updated 27 Aug 2026
Stanley Appel, MD, is Peggy and Gary Edwards Distinguished Chair for ALS Research at Houston Methodist Academic Institute. The public record shows 507 publications with 37,192 citations (h-index 101), centered on ALS. It also documents an investigator role on 2 registered clinical trials, industry payments reported by 16 companies, 9 NIH-funded awards (1985–2014).
- Most recent indexed publication: 2026 · Nature neuroscience
- Top research focus: ALS
- 2 registered trials on ClinicalTrials.gov
- Open Payments reporting from 16 companies
Generated from the cited public record · current as of 27 Aug 2026. Every fact links its source below.
Indications focus
from trials led + research topicsResearch focus
OpenAlex concept fingerprintDrugs & molecules
across trials, industry payments and publicationsWorks with
trial sponsors and companies reporting paymentsScholarship
indexed output and impact (OpenAlex)Distinct works indexed by OpenAlex, matched via ORCID; 4 in PubMed.
Total citations across indexed works.
Hirsch index, productivity × impact (OpenAlex).
Clinical & industry
trials, payments and federal fundingContact
The practice address and phone this provider lists in the federal NPPES (CMS) registry.
Practice address
Telephone
Practice address and telephone from the federal NPPES registry.
Sign in to view contact details →Clinical trials
Updated 27 Aug 2026
Listed as an investigator on 2 registered studies on ClinicalTrials.gov. The most recent:
- T-regulatory Cells in ALS
Sponsor: The Methodist Hospital Research Institute
- Ph1 T-Regulatory Cells in Amyotrophic Lateral Sclerosis
Sponsor: The Methodist Hospital Research Institute
Industry payments
Updated 27 Aug 2026
16 companies reported payments to CMS in program years 2021–2025. These are public disclosures, not judgments. The latest:
- GlaxoSmithKline, LLC.Program year20251 payment
- Tanabe Pharma America, Inc.Program year20258 payments
- ABBVIE INC.Program year20251 payment
Medicare prescribing footprint (2024)
The drugs this prescriber writes for Medicare patients, grouped by drug class and therapeutic area. Every percentage is a share of their total prescribing, so you can see what they prescribe most. These are proportions, not patient counts or dollar amounts. No condition is inferred: the claims record what was prescribed, never why.
Nervous system
97.7%Other nervous system drugs42.3%Radicava Ors100%Part D≥35 patientsBenzothiazole38.6%Riluzole100%Part D≥74 patientsMusculoskeletal
2.3%gamma-Aminobutyric Acid-ergic Agonist2.3%Baclofen100%Part D<11 patients
Drug classes come from the WHO ATC and U.S. National Library of Medicine (RxClass) classifications; prescribing counts come from the CMS Medicare Part D Prescribers file. Each drug is counted once, under its primary class. Medicare fee-for-service only, so no Medicare Advantage, commercial, or pediatric prescribing is included. CMS publishes this data about 17 months after the fact.
NIH funding
Updated 27 Aug 2026
9 NIH research awards on record, funded 1985–2014 per NIH RePORTER. The latest:
- Blocking TLR-Activation of Regulatory T cells Slows Disease in ALS
Methodist Hospital Research Institute
FY2014$233,888R21NS079943 - Blocking TLR-Activation of Regulatory T cells Slows Disease in ALS
Methodist Hospital Research Institute
FY2013$196,875R21NS079943 - Using CD4+ T cells as a candidate therapy to slow disease progression in ALS
Methodist Hospital Research Institute
FY2011$192,500R21NS067153
Publications
Updated 27 Aug 2026
Their five most recent publications, matched to their ORCID record and linked to PubMed.
- A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease.
Translational neurodegeneration
Letter2023 - Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease.
Acta neuropathologica communications
Article2022 - Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson's disease.
NPJ Parkinson's disease
Article2021
Online presence
Updated 27 Aug 2026
This person's own public accounts first, then places where others mention them. Two different things, listed separately.
Owned accounts
public accounts run by this person- Doximity
doximity.com/pub/stanley-appel-md
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →doximity.com ↗ - Other
scholars.houstonmethodist.org/en/persons/stanley-h-appel
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗ - ResearchGate
researchgate.net/profile/Stanley-Appel
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →researchgate.net ↗
Mentions by others
where others cite or feature them- LinkedIn
linkedin.com/posts/the-als-association_a-legacy-of-hope-dr-stanley-appels-personal-activity-7255680961638469632-4WGD
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →linkedin.com ↗ - Other
watch.houstonmethodist.org/media/Cell+Therapy+for+Neurological+Diseases++by+Stanley+H.+Appel,+MD/1_2axbkhok
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →watch.houstonmethodist.org ↗ - X / Twitter
x.com/CoyaTx/status/2022065962535498139
We list an account only when the public record ties it to this person. verified means we've confirmed the match in more than one place; provisional means it looks right but we're still confirming.
Background & recognition
Updated 27 Aug 2026
Credentials, appointments and honors, newest first, each linked to the public source it came from.
Education
degrees and training on record- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗
- BA
Harvard University
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗ - Board Certified
American Board of Psychiatry and Neurology (Neurology)
provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →wellness.com ↗
Editorial & leadership roles
journal and society appointments- Founder
one of the nation's first multidisciplinary ALS clinics, Houston Methodist Neurological Institute
1982provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →houstonmethodist.org ↗
Awards & honors
honors on the public record- provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →scholars.houstonmethodist.org ↗
- provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →scholars.houstonmethodist.org ↗
- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗
Secondary affiliations
appointments beyond the home institution- Professor of Neurology
Weill Cornell Medical College
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗ - Former Chief
Neurology Division and James B. Duke Professor of Medicine, Duke University Medical Center
provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →alsfindingacure.org ↗ - Houston Methodist Hospital
Professor and Chair (past, per ORCID-declared employment)
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →orcid.org ↗
Media & interviews
press, podcasts and appearances- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →neurologylive.com ↗
- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →neurologylive.com ↗
- provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →tmc.edu ↗
Every item links to where we found it. verified means we've confirmed it in more than one place; provisional means we found it and are still confirming.
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