Stanley Appel, MDEnriched profile
Peggy and Gary Edwards Distinguished Chair for ALS Research; Chair, Stanley H. Appel Department of Neurology; Co-Director, Houston Methodist Neurological Institute; Director, MDA/ALSA ALS Research Clinical Center; Director, Ann Kimball and John W. Johnson Center for Cellular Therapeutics · Houston Methodist Academic Institute
Overview
Updated 14 Jul 2026
Stanley Appel, MD, is Peggy and Gary Edwards Distinguished Chair for ALS Research at Houston Methodist Academic Institute. The public record shows 507 publications with 37,192 citations (h-index 101), centered on ALS. It also documents an investigator role on 2 registered clinical trials, industry payments reported by 16 companies, 9 NIH-funded awards (1985–2014).
- Most recent indexed publication: 2026 · Nature neuroscience
- Top research focus: ALS
- 2 registered trials on ClinicalTrials.gov
- Open Payments reporting from 16 companies
Generated from the cited public record · current as of 14 Jul 2026. Every fact links its source below.
Indications focusfrom trials led + research topics
Research focusOpenAlex concept fingerprint
Drugs & moleculesacross trials, industry payments and publications
Works withtrial sponsors and companies reporting payments
Scholarshipindexed output and impact (OpenAlex)
View publications ↓Distinct works indexed by OpenAlex, matched via ORCID; 4 in PubMed.
Total citations across indexed works.
Hirsch index, productivity × impact (OpenAlex).
Clinical & industrytrials, payments and federal funding
Clinical trials
Updated 14 Jul 2026
Listed as an investigator on 2 registered studies on ClinicalTrials.gov. The most recent:
- T-regulatory Cells in ALS
Sponsor: The Methodist Hospital Research Institute
InvestigatorPhase 2Active, not recruitingNCT04055623 - Ph1 T-Regulatory Cells in Amyotrophic Lateral Sclerosis
Sponsor: The Methodist Hospital Research Institute
InvestigatorPhase 1CompletedNCT03241784
Industry payments
Updated 14 Jul 2026
16 companies reported payments to CMS in program years 2021–2025. These are public disclosures, not judgments. The latest:
- GlaxoSmithKline, LLC.Program year20251 payment
- Tanabe Pharma America, Inc.Program year20258 payments
- ABBVIE INC.Program year20251 payment
NIH funding
Updated 14 Jul 2026
9 NIH research awards on record, funded 1985–2014 per NIH RePORTER. The latest:
- Blocking TLR-Activation of Regulatory T cells Slows Disease in ALS
Methodist Hospital Research Institute
FY2014$233,888R21NS079943 - Blocking TLR-Activation of Regulatory T cells Slows Disease in ALS
Methodist Hospital Research Institute
FY2013$196,875R21NS079943 - Using CD4+ T cells as a candidate therapy to slow disease progression in ALS
Methodist Hospital Research Institute
FY2011$192,500R21NS067153
Publications
Updated 14 Jul 2026
Their five most recent publications, matched to their ORCID record and linked to PubMed.
- A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease.
Translational neurodegeneration
2023 - Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease.
Acta neuropathologica communications
2022
Contact
An office address from a public listing. This research profile has no federal registry record to draw from.
Office address
6560 Fannin Street, Suite 802, Houston, TX 77030
Background & recognition
Updated 14 Jul 2026
Credentials, appointments and honors, newest first, each linked to the public source it came from.
Educationdegrees and training on record
- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗
- BA
Harvard University
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗ - Board Certified
American Board of Psychiatry and Neurology (Neurology)
provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →wellness.com ↗
Editorial & leadership rolesjournal and society appointments
- Founder
one of the nation's first multidisciplinary ALS clinics, Houston Methodist Neurological Institute
1982provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →houstonmethodist.org ↗
Awards & honorshonors on the public record
- provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →scholars.houstonmethodist.org ↗
- provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →scholars.houstonmethodist.org ↗
- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗
Secondary affiliationsappointments beyond the home institution
- Professor of Neurology
Weill Cornell Medical College
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗ - Former Chief
Neurology Division and James B. Duke Professor of Medicine, Duke University Medical Center
provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →alsfindingacure.org ↗ - Houston Methodist Hospital
Professor and Chair (past, per ORCID-declared employment)
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →orcid.org ↗
Media & interviewspress, podcasts and appearances
- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →neurologylive.com ↗
- verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →neurologylive.com ↗
- provisionalFound in a cited public source but not yet independently corroborated. Published as a labeled candidate and queued for verification.How we verify →tmc.edu ↗
Every item links to where we found it. verified means we've confirmed it in more than one place; provisional means we found it and are still confirming.
Online presence
Updated 14 Jul 2026
This person's own public accounts first, then places where others mention them. Two different things, listed separately.
Owned accountspublic accounts run by this person
- Doximity
doximity.com/pub/stanley-appel-md
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →doximity.com ↗ - Other
scholars.houstonmethodist.org/en/persons/stanley-h-appel
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →scholars.houstonmethodist.org ↗ - ResearchGate
researchgate.net/profile/Stanley-Appel
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →researchgate.net ↗
Mentions by otherswhere others cite or feature them
- LinkedIn
linkedin.com/posts/the-als-association_a-legacy-of-hope-dr-stanley-appels-personal-activity-7255680961638469632-4WGD
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →linkedin.com ↗ - Other
watch.houstonmethodist.org/media/Cell+Therapy+for+Neurological+Diseases++by+Stanley+H.+Appel,+MD/1_2axbkhok
verifiedCorroborated by findmyKOL. We matched this record across two or more independent public sources (or a verified ORCID / NPI identifier bridge) before attributing it to this person.How we verify →watch.houstonmethodist.org ↗ - X / Twitter
x.com/CoyaTx/status/2022065962535498139
We list an account only when the public record ties it to this person. verified means we've confirmed the match in more than one place; provisional means it looks right but we're still confirming.
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