Clinical trialNCT00000488CompletedPhase 3Interventional

Lipid Research Clinics Coronary Primary Prevention Trial (CPPT)

SponsorNational Heart, Lung, and Blood Institute (NHLBI)Cardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial Ischemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

To determine whether reduction of cholesterol by drug therapy significantly lowered the atherosclerotic coronary heart disease rate in a group of hypercholesterolemic but otherwise healthy men. Total dollars spent on the CPPT from June 1973 were $142,250,000. We do not have a year-by-year breakdown.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Anne Goldberg
Washington University School of Medicine
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Dennis Sprecher
University of Cincinnati
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Elizabeth Barrett-Connor
University of California, San Diego
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Francois Abboud
University of Iowa
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Frank Ibbott
Bio-Science Laboratories
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Gerald Cooper
Centers for Disease Control and Prevention
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Ivan Frantz
University of Minnesota
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J. Little
University of Toronto
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John Farquhar
Stanford University
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John LaRosa
George Washington University
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L. Sheffield
University of Alabama at Birmingham
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Marilyn Buzzard
University of Minnesota
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Peter Kwiterovich
Johns Hopkins University
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Reagan Bradford
Oklahoma Medical Research Foundation
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Robert Knoop
University of Washington
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William, Insull
Baylor College of Medicine
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

No facility list is in our current data snapshot for this study. The registry record on ClinicalTrials.gov ↗ carries any published locations. Why? →

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cholestyramine resin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 1973
Primary completion: —
Completion: 31 Oct 1989
Last update posted: 14 Apr 2016
Registered enrollment: —
Registry id: NCT00000488

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.