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Clinical trialNCT00000919CompletedInterventional

A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV Infection

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment900HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to compare the effectiveness of various combinations of anti-HIV drugs in HIV-positive men and women. Patients receive specific combinations of 3 or 4 of the following 6 drugs: didanosine (ddI), stavudine (d4T) efavirenz (EFV), nelfinavir (NFV), lamivudine (3TC), or zidovudine (ZDV). Anti-HIV therapy is effective in preventing the spread of HIV in the body. However, patients often experience unpleasant side effects and have difficulties following the dosing schedule. This study looks for combinations of anti-HIV drugs ("cocktails") which will be the most effective with the fewest problems.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

80 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Italy
  • Azienda Ospedaliera Umberto I

    Ancona, Italy

  • Ospedale S Orsola

    Bologna, Italy

  • Spedali Civili - Carosi

    Brescia, Italy

  • Spedali Civili Cadeo

    Brescia, Italy

  • Archispedale S Anna

    Ferrara, Italy

  • Universita Di Genova

    Genova, Italy

  • Ospedale Luigi Cacco Moroni

    Milan, Italy

  • Ospedale Luigi Sacco Cargnel

    Milan, Italy

  • Azienda Ospedaliera Di Parma

    Parma, Italy

  • Irccs Policlinico S Matteo Filice

    Pavia, Italy

  • Irccs Policlinico S Matteo Minoli

    Pavia, Italy

  • Archispedale S Maria Nuova

    Reggio Emilia, Italy

  • Universita Di Roma - Delia

    Roma, Italy

  • Ospedale Civile Maggiore

    Verona, Italy

Puerto Rico
  • Univ of Puerto Rico

    San Juan, Puerto Rico

United States
  • Univ of Alabama at Birmingham

    Birmingham, Alabama, United States

  • Ucla Care Ctr

    Los Angeles, California, United States

  • Univ of Southern California / la County Usc Med Ctr

    Los Angeles, California, United States

  • Willow Clinic

    Menlo Park, California, United States

  • Univ of California / San Diego Treatment Ctr

    San Diego, California, United States

  • San Francisco Aids Clinic / San Francisco Gen Hosp

    San Francisco, California, United States

  • San Francisco Gen Hosp

    San Francisco, California, United States

  • Santa Clara Valley Med Ctr / Aids Community Rsch Consortium

    San Jose, California, United States

  • Marin County Specialty Clinic

    San Rafael, California, United States

  • San Mateo Aids Program / Stanford Univ

    Stanford, California, United States

  • Stanford Univ Med Ctr

    Stanford, California, United States

  • Harbor Ucla Med Ctr

    Torrance, California, United States

  • Univ of Colorado Health Sciences Ctr

    Denver, Colorado, United States

  • Georgetown Univ Hosp

    Washington D.C., District of Columbia, United States

  • Howard Univ

    Washington D.C., District of Columbia, United States

  • Univ of Miami School of Medicine

    Miami, Florida, United States

  • Emory Hemo Comp Evaluation Clinic / East Tn Comp Hemo Ctr

    Atlanta, Georgia, United States

  • Emory Univ

    Atlanta, Georgia, United States

  • Univ of Hawaii

    Honolulu, Hawaii, United States

  • Cook County Hosp

    Chicago, Illinois, United States

  • Northwestern Univ Med School

    Chicago, Illinois, United States

  • Rush Presbyterian - Saint Luke'S Med Ctr

    Chicago, Illinois, United States

  • Division of Inf Diseases/ Indiana Univ Hosp

    Indianapolis, Indiana, United States

  • Indiana Univ Hosp

    Indianapolis, Indiana, United States

  • Methodist Hosp of Indiana / Life Care Clinic

    Indianapolis, Indiana, United States

40 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Abacavir →AmprenavirDidanosineEfavirenz →Hydroxyurea →Indinavir →Lamivudine →Nelfinavir →Ritonavir →Stavudine →Zidovudine →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
—
Primary completion
—
Completion
30 Nov 2002
Last update posted
7 Jun 2012
Registered enrollment
900
Registry id
NCT00000919
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.