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Clinical trialNCT00000949CompletedPhase 3Interventional

A Study to Evaluate the Effects of Giving Proleukin (rIL-2) to HIV-Positive Patients With CD4 Counts Greater Than 300 Cells/mm3

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment460HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to examine how rIL-2 affects HIV-positive patients with CD4 counts over 300 cells/mm3 who are on anti-HIV drug therapy. The drug rIL-2 has been shown to increase CD4 cell counts, which help the body fight off HIV. There is strong evidence that rIL-2 increases CD4 cell counts (cells of the immune system that fight infection). This study examines the effect of 2 different amounts of rIL-2 on CD4 cell count and the amount of HIV in the blood (viral burden).
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Community Consortium / Ucsf

    San Francisco, California, United States

  • Denver Cpcra / Denver Public Hlth

    Denver, Colorado, United States

  • Washington Reg Aids Prog / Dept of Infect Dis

    Washington D.C., District of Columbia, United States

  • Aids Research Consortium of Atlanta

    Atlanta, Georgia, United States

  • Aids Research Alliance - Chicago

    Chicago, Illinois, United States

  • Louisiana Comm Aids Rsch Prog / Tulane Univ Med

    New Orleans, Louisiana, United States

  • Henry Ford Hosp

    Detroit, Michigan, United States

  • Wayne State Univ - Wsu/dmc / Univ Hlth Ctr

    Detroit, Michigan, United States

  • Southern New Jersey Aids Clinical Trials

    Camden, New Jersey, United States

  • North Jersey Community Research Initiative

    Newark, New Jersey, United States

  • Partners in Research / New Mexico

    Albuquerque, New Mexico, United States

  • Harlem Aids Treatment Grp / Harlem Hosp Ctr

    New York, New York, United States

  • the Research and Education Group

    Portland, Oregon, United States

  • Philadelphia Fight

    Philadelphia, Pennsylvania, United States

  • Richmond Aids Consortium / Div of Infect Diseases

    Richmond, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Aldesleukin
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
—
Primary completion
—
Completion
31 Jul 2000
Last update posted
29 Oct 2021
Registered enrollment
460
Registry id
NCT00000949
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.