Clinical trialNCT00000950CompletedInterventional

Metabolism of Antituberculosis Drugs in HIV-Infected Persons With Tuberculosis

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment50HIV InfectionsTuberculosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine if a relationship exists between the level of antituberculosis drugs (isoniazid, rifampin, ethambutol, and pyrazinamide) in the blood and the outcome of HIV-positive patients with tuberculosis. This study also evaluates how these drugs are absorbed and metabolized in the body.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David Perlman
Study Chair
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Keith Chirgwin
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Univ of Southern California / la County Usc Med Ctr
Los Angeles, California, United States
Harbor Ucla Med Ctr
Torrance, California, United States
University of Miami (pediatric)
Miami, Florida, United States
Emory Univ
Atlanta, Georgia, United States
Queens Med Ctr
Honolulu, Hawaii, United States
Univ of Hawaii
Honolulu, Hawaii, United States
Tulane Univ School of Medicine
New Orleans, Louisiana, United States
Suny / Health Sciences Ctr at Brooklyn
Brooklyn, New York, United States
Beth Israel Med Ctr
New York, New York, United States
Mount Sinai Med Ctr
New York, New York, United States
St Vincent'S Hosp / Mem Sloan-Kettering Cancer Ctr
New York, New York, United States
Metrohealth Med Ctr
Cleveland, Ohio, United States
Univ of Pennsylvania at Philadelphia
Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ethambutol →Isoniazid →Pyrazinamide →PyridoxineRifampin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: —
Primary completion: 31 May 2002
Completion: —
Last update posted: 2 Mar 2011
Registered enrollment: 50
Registry id: NCT00000950

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.