Clinical trialNCT00001132CompletedPhase 2Interventional

Effectiveness of the Early Addition of Abacavir to an Anti-HIV Drug Combination

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment80HIV Infections

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to see if adding 1 drug to an anti-HIV drug combination early in treatment against HIV can lower the viral load (amount of HIV in the blood) to a level so low that it cannot be measured (undetectable). The drug that will be added to a treatment is abacavir (ABC). Many patients who take 3 anti-HIV drugs together are able to achieve very low viral loads, for example, viral loads below 50 copies/ml. However, some patients taking only 3 drugs are not able to achieve a viral load this low. Doctors hope that, by adding the drug ABC to a current treatment, a viral load below 50 copies/ml can be achieved. Doctors would like to find out if it is effective to start patients on 3 drugs and then add another drug (treatment intensification) if the treatment is not working as well as hoped.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

John Bartlett
Study Chair
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Pablo Tebas
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

30 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Univ of Puerto Rico
San Juan, Puerto Rico

United States

Ucla Care Ctr
Los Angeles, California, United States
Willow Clinic
Menlo Park, California, United States
Santa Clara Valley Med Ctr / Aids Community Rsch Consortium
San Jose, California, United States
San Mateo Aids Program / Stanford Univ
Stanford, California, United States
Stanford Univ Med Ctr
Stanford, California, United States
Harbor Ucla Med Ctr
Torrance, California, United States
Univ of Colorado Health Sciences Ctr
Denver, Colorado, United States
Univ of Miami School of Medicine
Miami, Florida, United States
Emory Univ
Atlanta, Georgia, United States
Cook County Hosp
Chicago, Illinois, United States
Northwestern Univ Med School
Chicago, Illinois, United States
Johns Hopkins Hosp
Baltimore, Maryland, United States
State of Md Div of Corrections / Johns Hopkins Univ Hosp
Baltimore, Maryland, United States
St Louis Regional Hosp / St Louis Regional Med Ctr
St Louis, Missouri, United States
Suny / Erie County Med Ctr at Buffalo
Buffalo, New York, United States
Aaron Diamond Aids Rsch Ctr / Rockefeller Univ
New York, New York, United States
Bellevue Hosp / New York Univ Med Ctr
New York, New York, United States
Beth Israel Med Ctr
New York, New York, United States
Columbia Presbyterian Med Ctr
New York, New York, United States
Univ of Rochester Medical Center
Rochester, New York, United States
Univ of North Carolina
Chapel Hill, North Carolina, United States
Duke Univ Med Ctr
Durham, North Carolina, United States
Univ of Cincinnati
Cincinnati, Ohio, United States
Philadelphia Veterans Administration Med Ctr
Philadelphia, Pennsylvania, United States
Univ of Pennsylvania at Philadelphia
Philadelphia, Pennsylvania, United States
Julio Arroyo
West Columbia, South Carolina, United States
Vanderbilt Univ Med Ctr
Nashville, Tennessee, United States
Univ of Texas, Southwestern Med Ctr of Dallas
Dallas, Texas, United States
Univ of Washington
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Abacavir →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 1999
Primary completion: —
Completion: 30 Apr 2001
Last update posted: 9 Sept 2008
Registered enrollment: 80
Registry id: NCT00001132

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.