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Clinical trialNCT00002496CompletedPhase 3Interventional

Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Cancer of the Larynx

SponsorRadiation Therapy Oncology GroupHead and Neck Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known if chemotherapy plus radiation therapy is more effective than radiation therapy alone in treating patients with advanced cancer of the larynx. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without chemotherapy in treating patients with advanced cancer of the larynx.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Africa
  • Pretoria Academic Hospital

    Pretoria, South Africa

United States
  • Ccop - Colorado Cancer Research Program, Inc.

    Denver, Colorado, United States

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, United States

  • Veterans Affairs Medical Center - Atlanta (decatur)

    Decatur, Georgia, United States

  • Ccop - Illinois Oncology Research Association

    Peoria, Illinois, United States

  • Ccop - Carle Cancer Center

    Urbana, Illinois, United States

  • Indiana University Cancer Center

    Indianapolis, Indiana, United States

  • Veterans Affairs Medical Center - Indianapolis (roudebush)

    Indianapolis, Indiana, United States

  • Ccop - Iowa Oncology Research Association

    Des Moines, Iowa, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, United States

  • New England Medical Center Hospital

    Boston, Massachusetts, United States

  • Ccop - Kalamazoo

    Kalamazoo, Michigan, United States

  • Ccop - Metro-Minnesota

    Saint Louis Park, Minnesota, United States

  • Veterans Affairs Medical Center - East Orange

    East Orange, New Jersey, United States

  • Ccop - Northern New Jersey

    Hackensack, New Jersey, United States

  • Ireland Cancer Center

    Cleveland, Ohio, United States

  • Hahnemann University Hospital

    Philadelphia, Pennsylvania, United States

  • University of Pittsburgh Cancer Institute

    Pittsburgh, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Chemotherapy →Cisplatin →Fluorouracil →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Aug 1992
Primary completion
31 Aug 2002
Completion
30 Nov 2013
Last update posted
24 Jan 2014
Registered enrollment
—
Registry id
NCT00002496
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.