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Clinical trialNCT00002618CompletedPhase 3Interventional

Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma

SponsorChildren's Oncology GroupEnrollment242Lymphoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different doses may kill more cancer cells. PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy with various combinations of drugs in treating pediatric patients with advanced-stage large cell lymphoma.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

10 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico
  • University of Puerto Rico School of Medicine Medical Sciences Campus

    San Juan, Puerto Rico

Switzerland
  • Clinique de Pediatrie

    Geneva, Switzerland

United States
  • Via Christi Regional Medical Center-Saint Francis Campus

    Wichita, Kansas, United States

  • Mbccop - Lsu Medical Center

    New Orleans, Louisiana, United States

  • Memorial Mission Hospital

    Asheville, North Carolina, United States

  • Medical University of South Carolina

    Charleston, South Carolina, United States

  • Medical City Dallas Hospital

    Dallas, Texas, United States

  • San Antonio Military Pediatric Cancer and Blood Disorders Center

    Lackland Air Force Base, Texas, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, United States

  • Cancer Center, University of Virginia Hsc

    Charlottesville, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cytarabine →Doxorubicin →Filgrastim →Leucovorin →Mercaptopurine →Methotrexate →Prednisone →Vincristine →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Dec 1994
Primary completion
30 Sept 2000
Completion
30 Sept 2006
Last update posted
24 Jul 2014
Registered enrollment
242
Registry id
NCT00002618
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.