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Clinical trialNCT00002631CompletedPhase 3Interventional

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Cancer of the Esophagus

SponsorRadiation Therapy Oncology GroupEnrollment298Esophageal Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not known whether high-dose radiation therapy is more effective than standard dose radiation therapy in treating cancer of the esophagus. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy plus high- or standard-dose radiation therapy in treating patients with cancer of the esophagus.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Saskatchewan Cancer Agency

    Regina, Saskatchewan, Canada

United States
  • Ccop - Scottsdale Oncology Program

    Scottsdale, Arizona, United States

  • Ccop - Illinois Oncology Research Association

    Peoria, Illinois, United States

  • Ccop - Carle Cancer Center

    Urbana, Illinois, United States

  • Ccop - Cedar Rapids Oncology Project

    Cedar Rapids, Iowa, United States

  • Ccop - Iowa Oncology Research Association

    Des Moines, Iowa, United States

  • Siouxland Hematology-Oncology

    Sioux City, Iowa, United States

  • Ccop - Wichita

    Wichita, Kansas, United States

  • Ccop - Duluth

    Duluth, Minnesota, United States

  • Mayo Clinic Cancer Center

    Rochester, Minnesota, United States

  • Centracare Clinic

    Saint Cloud, Minnesota, United States

  • Quain & Ramstad Clinic, P.C.

    Bismarck, North Dakota, United States

  • Ccop - Merit Care Hospital

    Fargo, North Dakota, United States

  • Altru Health Systems

    Grand Forks, North Dakota, United States

  • Ccop - Toledo Community Hospital Oncology Program

    Toledo, Ohio, United States

  • Ccop - Geisinger Clinical and Medical Center

    Danville, Pennsylvania, United States

  • Rapid City Regional Hospital

    Rapid City, South Dakota, United States

  • Ccop - Sioux Community Cancer Consortium

    Sioux Falls, South Dakota, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Chemotherapy →Cisplatin →Fluorouracil →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Jun 1995
Primary completion
30 Sept 1999
Completion
—
Last update posted
19 Nov 2013
Registered enrollment
298
Registry id
NCT00002631
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.