Clinical trialNCT00002756CompletedPhase 2Interventional

Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia

SponsorChildren's Oncology GroupEnrollment221Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one chemotherapy drug and giving them as induction intensification may kill more cancer cells. PURPOSE: This phase II trial is studying how well induction intensification works in treating infants with newly diagnosed acute lymphocytic leukemia.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Zoann E. Dreyer, MD
Texas Children's Cancer Center
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

140 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Princess Margaret Hospital for Children
Perth, Western Australia, Australia

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Children'S & Women'S Hospital of British Columbia
Vancouver, British Columbia, Canada
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Iwk Health Centre
Halifax, Nova Scotia, Canada
Hospital for Sick Children
Toronto, Ontario, Canada
Montreal Children'S Hospital at Mcgill University Health Center
Montreal, Quebec, Canada
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, Canada
Saskatoon Cancer Centre at the University of Saskatchewan
Saskatoon, Saskatchewan, Canada

Switzerland

Swiss Pediatric Oncology Group Bern
Bern, Switzerland
Swiss Pediatric Oncology Group Geneva
Geneva, Switzerland
Swiss Pediatric Oncology Group Lausanne
Lausanne, Switzerland

United States

Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham, Alabama, United States
Phoenix Children'S Hospital
Phoenix, Arizona, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Southern California Permanente Medical Group
Downey, California, United States
Loma Linda University Cancer Institute at Loma Linda University Medical Center
Loma Linda, California, United States
Jonathan Jaques Children'S Cancer Center at Miller Children'S Hospital
Long Beach, California, United States
Children'S Hospital Central California
Madera, California, United States
Children'S Hospital and Research Center - Oakland
Oakland, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Kaiser Permanente Medical Center - Oakland
Sacramento, California, United States
Sutter Cancer Center
Sacramento, California, United States
Children'S Hospital and Health Center - San Diego
San Diego, California, United States
Ucsf Comprehensive Cancer Center
San Francisco, California, United States
Santa Barbara Cottage Children'S Hospital
Santa Barbara, California, United States
Stanford Cancer Center at Stanford University Medical Center
Stanford, California, United States
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
Farmington, Connecticut, United States
Yale Cancer Center
New Haven, Connecticut, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Broward General Medical Center Cancer Center
Fort Lauderdale, Florida, United States
Lee Cancer Care of Lee Memorial Health System
Fort Myers, Florida, United States
University of Florida Shands Cancer Center
Gainesville, Florida, United States
Nemours Children'S Clinic
Jacksonville, Florida, United States
Baptist-South Miami Regional Cancer Program
Miami, Florida, United States
Florida Hospital Cancer Institute at Florida Hospital Orlando
Orlando, Florida, United States
Nemours Children'S Clinic - Orlando
Orlando, Florida, United States
Sacred Heart Cancer Center at Sacred Heart Hospital
Pensacola, Florida, United States
St. Joseph'S Cancer Institute at St. Joseph'S Hospital
Tampa, Florida, United States
Kaplan Cancer Center at St. Mary'S Medical Center
West Palm Beach, Florida, United States

100 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Asparaginase →Cyclophosphamide →Cytarabine →Daunorubicin →Etoposide →Filgrastim →Leucovorin →Mercaptopurine →Methotrexate →Prednisone →Therapeutic hydrocortisoneVincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 1996
Primary completion: 30 Sept 2007
Completion: 31 Mar 2012
Last update posted: 14 Feb 2014
Registered enrollment: 221
Registry id: NCT00002756

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.