Clinical trialNCT00002912CompletedPhase 1Interventional

Combination Chemotherapy Plus PSC-833 in Treating Children With Refractory or Relapsed Acute Leukemia

SponsorNational Cancer Institute (NCI)Enrollment3Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Phase I trial to study the effectiveness of PSC-833 plus etoposide and mitoxantrone in treating children who have refractory or relapsed acute leukemia. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Some cancers become resistant to chemotherapy drugs. Combining PSC-833 with chemotherapy may reduce resistance to the drug and allow more cancer cells to be killed.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Gary V.H. Dahl, MD
Lucile Packard Children's Hospital at Stanford University Medical Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

55 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Royal Children'S Hospital
Parkville, Victoria, Australia
Princess Margaret Hospital for Children
Perth, Western Australia, Australia

Canada

Hospital for Sick Children
Toronto, Ontario, Canada
Hopital Sainte Justine
Montreal, Quebec, Canada
Montreal Children'S Hospital
Montreal, Quebec, Canada

United States

University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
University of California San Diego Cancer Center
La Jolla, California, United States
Children'S Hospital Los Angeles
Los Angeles, California, United States
City of Hope National Medical Center
Los Angeles, California, United States
Jonsson Comprehensive Cancer Center, Ucla
Los Angeles, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Ucsf Cancer Center and Cancer Research Institute
San Francisco, California, United States
Stanford University Medical Center
Stanford, California, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
University of Florida Health Science Center
Gainesville, Florida, United States
Emory University Hospital - Atlanta
Atlanta, Georgia, United States
Children'S Memorial Hospital, Chicago
Chicago, Illinois, United States
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, United States
Indiana University Cancer Center
Indianapolis, Indiana, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Johns Hopkins Oncology Center
Baltimore, Maryland, United States
Boston Floating Hospital Infants and Children
Boston, Massachusetts, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Children'S Hospital of Michigan
Detroit, Michigan, United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, United States
University of Mississippi Medical Center
Jackson, Mississippi, United States
Children'S Mercy Hospital
Kansas City, Missouri, United States
Cardinal Glennon Children'S Hospital
St Louis, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
Hackensack University Medical Center
Hackensack, New Jersey, United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
Columbia Presbyterian Hospital
New York, New York, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
Nyu School of Medicine'S Kaplan Comprehensive Cancer Center
New York, New York, United States
State University of New York - Upstate Medical University
Syracuse, New York, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, United States
Children'S Hospital Medical Center - Cincinnati
Cincinnati, Ohio, United States

15 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Etoposide →MitoxantroneVALSPODAR

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 1997
Primary completion: 31 Mar 2006
Completion: —
Last update posted: 1 Feb 2013
Registered enrollment: 3
Registry id: NCT00002912

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.