Clinical trialNCT00003019CompletedPhase 2Interventional

Vinblastine and Methotrexate in Treating Children With Desmoid Tumors

SponsorChildren's Oncology GroupEnrollment28Desmoid Tumor

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of chemotherapy with vinblastine and methotrexate in treating children who have desmoid tumors that are recurrent or untreatable with surgery or radiation therapy.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Bruce Himelstein, MD
Children's Hospital of Philadelphia
Study Chair
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Steve Skapek, MD
St. Jude Children's Research Hospital
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

39 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Princess Margaret Hospital for Children
Perth, Western Australia, Australia

Canada

British Columbia Children'S Hospital
Vancouver, British Columbia, Canada
Iwk Grace Health Centre
Halifax, Nova Scotia, Canada

United States

Long Beach Memorial Medical Center
Long Beach, California, United States
Children'S Hospital Los Angeles
Los Angeles, California, United States
Jonsson Comprehensive Cancer Center, Ucla
Los Angeles, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Ucsf Cancer Center and Cancer Research Institute
San Francisco, California, United States
David Grant Medical Center
Travis Air Force Base, California, United States
Children'S Hospital of Denver
Denver, Colorado, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
University of Chicago Cancer Research Center
Chicago, Illinois, United States
Indiana University Cancer Center
Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Ccop - Kalamazoo
Kalamazoo, Michigan, United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, United States
Children'S Mercy Hospital
Kansas City, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Herbert Irving Comprehensive Cancer Center
New York, New York, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
Nyu School of Medicine'S Kaplan Comprehensive Cancer Center
New York, New York, United States
Lineberger Comprehensive Cancer Center, Unc
Chapel Hill, North Carolina, United States
Ccop - Merit Care Hospital
Fargo, North Dakota, United States
Veterans Affairs Medical Center - Fargo
Fargo, North Dakota, United States
Children'S Hospital Medical Center - Cincinnati
Cincinnati, Ohio, United States
Ireland Cancer Center
Cleveland, Ohio, United States
Children'S Hospital of Columbus
Columbus, Ohio, United States
Doernbecher Children'S Hospital
Portland, Oregon, United States
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Children'S Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States
Vanderbilt Cancer Center
Nashville, Tennessee, United States
University of Texas - Md Anderson Cancer Center
Houston, Texas, United States
Huntsman Cancer Institute
Salt Lake City, Utah, United States
Children'S Hospital and Regional Medical Center - Seattle
Seattle, Washington, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Methotrexate →Vinblastine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Aug 1997
Primary completion: 31 Jul 2003
Completion: 30 Sept 2006
Last update posted: 25 Jul 2014
Registered enrollment: 28
Registry id: NCT00003019

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.