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Clinical trialNCT00003309CompletedPhase 2Interventional

Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer

SponsorEastern Cooperative Oncology GroupEnrollment33Brain and Central Nervous System Tumors
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug and combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by radiation therapy in treating adult patients with brain cancer.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, United States

  • Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Chicago, Illinois, United States

  • Veterans Affairs Medical Center - Lakeside Chicago

    Chicago, Illinois, United States

  • Ccop - Carle Cancer Center

    Urbana, Illinois, United States

  • Ccop - Cedar Rapids Oncology Project

    Cedar Rapids, Iowa, United States

  • Ccop - Iowa Oncology Research Association

    Des Moines, Iowa, United States

  • Ccop - Wichita

    Wichita, Kansas, United States

  • Ccop - Kalamazoo

    Kalamazoo, Michigan, United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan, United States

  • Ccop - Metro-Minnesota

    Saint Louis Park, Minnesota, United States

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, United States

  • Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center

    Nashville, Tennessee, United States

  • Ccop - Marshfield Clinic Research Foundation

    Marshfield, Wisconsin, United States

  • Medical College of Wisconsin Cancer Center

    Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cisplatin →Cyclophosphamide →Etoposide →Filgrastim →Vincristine →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
4 May 1999
Primary completion
31 Mar 2004
Completion
—
Last update posted
22 Jun 2023
Registered enrollment
33
Registry id
NCT00003309
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.