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Clinical trialNCT00003624TerminatedPhase 2Interventional

Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer

SponsorGynecologic Oncology GroupCervical CancerEndometrial CancerFallopian Tube CancerNeurotoxicityOvarian CancerPrimary Peritoneal Cavity Cancer+1 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy. PURPOSE: Phase II trial to study the effectiveness of amifostine in reducing the risk of side effects caused by cisplatin and paclitaxel in treating women who have ovarian, peritoneal, cervical, fallopian tube, uterine, or endometrial cancer.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Chao Family Comprehensive Cancer Center

    Orange, California, United States

  • Vincent T. Lombardi Cancer Research Center, Georgetown University

    Washington D.C., District of Columbia, United States

  • Emory University Hospital - Atlanta

    Atlanta, Georgia, United States

  • University of Chicago Cancer Research Center

    Chicago, Illinois, United States

  • Indiana University Cancer Center

    Indianapolis, Indiana, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Lineberger Comprehensive Cancer Center, Unc

    Chapel Hill, North Carolina, United States

  • Cleveland Clinic Cancer Center

    Cleveland, Ohio, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Amifostine →Cisplatin →Paclitaxel →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Dec 1998
Primary completion
31 Jan 2004
Completion
—
Last update posted
11 Apr 2013
Registered enrollment
—
Registry id
NCT00003624
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.