Clinical trialNCT00003644CompletedPhase 3Interventional

Carboplatin Plus Paclitaxel With or Without Continued Low-Dose Paclitaxel in Treating Patients With Early-Stage Ovarian Cancer

SponsorGynecologic Oncology GroupEnrollment571Ovarian Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether receiving combined carboplatin and paclitaxel plus continued low-dose paclitaxel is more effective than carboplatin and paclitaxel alone for early-stage ovarian cancer. PURPOSE: This randomized phase III trial is studying carboplatin and paclitaxel alone too see how well they work compared to carboplatin and paclitaxel together with continued low-dose paclitaxel in treating patients with early-stage ovarian cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David S. Alberts, MD
University of Arizona
Study Chair
clinicaltrials.gov ↗
Robert S. Mannel, MD
University of Oklahoma College of Medicine
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

151 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Japan

Kagoshima City Hospital
Kagoshima City, Kagoshima, Japan
Kobe Medical Center
Kobe, Japan
Shikoku Cancer Center
Matsuyama, Japan
National Kyushu Cancer Center
Minamiku, Japan
Tohoku University Graduate School of Medicine
Sendai, Japan
National Cancer Center Hospital
Tokyo, Japan
Tottori University Hospital
Tottori, Japan

United States

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States
Banner Thunderbird Medical Center
Glendale, Arizona, United States
Banner Good Samaritan Medical Center
Phoenix, Arizona, United States
Ccop - Western Regional, Arizona
Phoenix, Arizona, United States
Highlands Oncology Group - Fayetteville
Fayetteville, Arkansas, United States
Washington Regional Medical Center
Fayetteville, Arkansas, United States
Alta Bates Comprehensive Cancer Center
Berkeley, California, United States
Peninsula Medical Center
Burlingame, California, United States
Marin Cancer Institute at Marin General Hospital
Greenbrae, California, United States
Sutter Health - Western Division Cancer Research Group
Greenbrae, California, United States
Todd Cancer Institute at Long Beach Memorial Medical Center
Long Beach, California, United States
Jonsson Comprehensive Cancer Center at Ucla
Los Angeles, California, United States
Kaiser Permanente Medical Center - Los Angeles
Los Angeles, California, United States
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
Orange, California, United States
University of California Davis Cancer Center
Sacramento, California, United States
California Pacific Medical Center - California Campus
San Francisco, California, United States
Torrance Memorial Medical Center
Torrance, California, United States
Colorado Gynecologic Oncology Group P.C.
Aurora, Colorado, United States
North Colorado Medical Center
Greeley, Colorado, United States
Mckee Medical Center
Loveland, Colorado, United States
Helen and Harry Gray Cancer Center at Hartford Hospital
Hartford, Connecticut, United States
Ccop - Christiana Care Health Services
Newark, Delaware, United States
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Florida Hospital Cancer Institute at Florida Hospital Orlando
Orlando, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
Tampa, Florida, United States
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States
University of Chicago Cancer Research Center
Chicago, Illinois, United States
University of Illinois Cancer Center
Chicago, Illinois, United States
Evanston Northwestern Healthcare - Evanston Hospital
Evanston, Illinois, United States
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, United States
Joliet Oncology-Hematology Associates, Limited - West
Joliet, Illinois, United States

111 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Paclitaxel →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 1998
Primary completion: 31 Mar 2010
Completion: —
Last update posted: 4 Jun 2019
Registered enrollment: 571
Registry id: NCT00003644

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.