Clinical trialNCT00003935CompletedPhase 1Interventional

Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma

SponsorChildren's Oncology GroupEnrollment31Brain TumorsCentral Nervous System Tumors

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug with radiation therapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of vincristine plus etoposide and radiation therapy in treating children who have newly diagnosed brain stem glioma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David N. Korones, MD
James P. Wilmot Cancer Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

110 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Royal Children'S Hospital
Parkville, Victoria, Australia

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Cross Cancer Institute
Edmonton, Alberta, Canada
Children'S Hospital
Hamilton, Ontario, Canada
Children'S Hospital of Eastern Ontario
Ottawa, Ontario, Canada
Hospital for Sick Children
Toronto, Ontario, Canada
Hopital Sainte Justine
Montreal, Quebec, Canada
Mcgill University Health Center - Montreal Children'S Hospital
Montreal, Quebec, Canada
Centre Hospitalier de L'Universite Laval
Sainte-Foy, Quebec, Canada

Netherlands

Academisch Ziekenhuis Groningen
Groningen, Netherlands

Puerto Rico

San Jorge Childrens Hospital
Santurce, Puerto Rico

Switzerland

Swiss Pediatric Oncology Group Bern
Bern, Switzerland
Clinique de Pediatrie
Geneva, Switzerland

United States

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States
Mbccop - Gulf Coast
Mobile, Alabama, United States
Arizona Cancer Center
Tucson, Arizona, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
University of California San Diego Cancer Center
La Jolla, California, United States
Lucile Packard Children'S Hospital at Stanford
Palo Alto, California, United States
Sutter Cancer Center
Sacramento, California, United States
University of California Davis Medical Center
Sacramento, California, United States
Children'S Hospital and Health Center
San Diego, California, United States
Kaiser Permanente-Southern California Permanente Medical Group
San Diego, California, United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Yale Comprehensive Cancer Center
New Haven, Connecticut, United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, United States
Shands Hospital and Clinics, University of Florida
Gainesville, Florida, United States
Nemours Children'S Clinic
Jacksonville, Florida, United States
Baptist Hospital of Miami
Miami, Florida, United States
Miami Children'S Hospital
Miami, Florida, United States
Sylvester Cancer Center, University of Miami
Miami, Florida, United States
Walt Disney Memorial Cancer Institute
Orlando, Florida, United States
All Children'S Hospital
St. Petersburg, Florida, United States
Ccop - Florida Pediatric
Tampa, Florida, United States
St. Mary'S Hospital
West Palm Beach, Florida, United States
Emory University Hospital - Atlanta
Atlanta, Georgia, United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, United States
Tripler Army Medical Center
Honolulu, Hawaii, United States
Children'S Memorial Hospital, Chicago
Chicago, Illinois, United States
Rush-Presbyterian-St. Luke'S Medical Center
Chicago, Illinois, United States

70 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Etoposide →Vincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 1999
Primary completion: 31 Oct 2003
Completion: 31 Mar 2007
Last update posted: 28 Jul 2014
Registered enrollment: 31
Registry id: NCT00003935

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.