Clinical trialNCT00003937CompletedPhase 3Interventional

Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

SponsorChildren's Oncology GroupEnrollment253Cardiac ToxicitySarcoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Chemoprotective drugs such as dexrazoxane may protect normal cells from the side effects of chemotherapy. PURPOSE: Phase III trial to study the effectiveness of three combination chemotherapy regimens plus dexrazoxane in treating patients who have newly diagnosed nonmetastatic osteosarcoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Cindy Schwartz, MD
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

148 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Royal Children'S Hospital
Parkville, Victoria, Australia
Princess Margaret Hospital for Children
Perth, Western Australia, Australia

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Cross Cancer Institute
Edmonton, Alberta, Canada
British Columbia Children'S Hospital
Vancouver, British Columbia, Canada
Iwk Health Centre
Halifax, Nova Scotia, Canada
Children'S Hospital
Hamilton, Ontario, Canada
Children'S Hospital of Eastern Ontario
Ottawa, Ontario, Canada
Hospital for Sick Children
Toronto, Ontario, Canada
Hopital Sainte Justine
Montreal, Quebec, Canada
Mcgill University Health Center - Montreal Children'S Hospital
Montreal, Quebec, Canada
Centre Hospitalier de L'Universite Laval
Sainte-Foy, Quebec, Canada

Netherlands

Academisch Ziekenhuis Groningen
Groningen, Netherlands

Puerto Rico

San Jorge Childrens Hospital
Santurce, Puerto Rico

Switzerland

Swiss Pediatric Oncology Group Bern
Bern, Switzerland
Clinique de Pediatrie
Geneva, Switzerland

United States

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States
Mbccop - Gulf Coast
Mobile, Alabama, United States
Arizona Cancer Center
Tucson, Arizona, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
University of California San Diego Cancer Center
La Jolla, California, United States
Long Beach Memorial Medical Center
Long Beach, California, United States
Children'S Hospital Los Angeles
Los Angeles, California, United States
Jonsson Comprehensive Cancer Center, Ucla
Los Angeles, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Lucile Packard Children'S Hospital at Stanford
Palo Alto, California, United States
Sutter Cancer Center
Sacramento, California, United States
University of California Davis Medical Center
Sacramento, California, United States
Children'S Hospital and Health Center
San Diego, California, United States
Kaiser Permanente-Southern California Permanente Medical Group
San Diego, California, United States
Ucsf Cancer Center and Cancer Research Institute
San Francisco, California, United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
David Grant Medical Center
Travis Air Force Base, California, United States
Children'S Hospital of Denver
Denver, Colorado, United States
Yale Comprehensive Cancer Center
New Haven, Connecticut, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, United States
Shands Hospital and Clinics, University of Florida
Gainesville, Florida, United States
Nemours Children'S Clinic
Jacksonville, Florida, United States
Baptist Hospital of Miami
Miami, Florida, United States

108 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cisplatin →DexrazoxaneDoxorubicin →Etoposide →Ifosfamide →Methotrexate →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 1999
Primary completion: 31 Mar 2004
Completion: 30 Jun 2008
Last update posted: 5 Aug 2014
Registered enrollment: 253
Registry id: NCT00003937

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.