Clinical trialNCT00004054CompletedPhase 3Interventional

Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer

SponsorRadiation Therapy Oncology GroupEnrollment397Prostate Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Hormones can stimulate the production of prostate cancer cells. Hormone therapy may fight prostate cancer by reducing the production of androgens. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy plus radiation therapy is more effective with or without combination chemotherapy for prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy plus radiation therapy with or without combination chemotherapy in treating patients who have prostate cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Howard M. Sandler, MD
University of Michigan Rogel Cancer Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

54 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Saint John Regional Hospital
Saint John, New Brunswick, Canada
Cancer Care Ontario-London Regional Cancer Centre
London, Ontario, Canada

United States

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States
Foundation for Cancer Research and Education
Phoenix, Arizona, United States
Mount Diablo Medical Center
Concord, California, United States
Sutter Health Western Division Cancer Research Group
Greenbrae, California, United States
Ccop - Santa Rosa Memorial Hospital
Santa Rosa, California, United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center
Denver, Colorado, United States
Baptist Hospital of Miami
Miami, Florida, United States
Lutheran General Cancer Care Center
Park Ridge, Illinois, United States
Methodist Cancer Center at Methodist Hospital
Indianapolis, Indiana, United States
Ball Memorial Hospital Cancer Center
Muncie, Indiana, United States
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States
Ccop - Ochsner
New Orleans, Louisiana, United States
Anne Arundel Oncology Center
Annapolis, Maryland, United States
Greater Baltimore Medical Center and Cancer Center
Baltimore, Maryland, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
West Michigan Cancer Center
Kalamazoo, Michigan, United States
Marquette General Hospital
Marquette, Michigan, United States
Ccop - Metro-Minnesota
Saint Louis Park, Minnesota, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, United States
Ccop - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, United States
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, United States
Monmouth Medical Center
Long Branch, New Jersey, United States
South Jersey Regional Cancer Center
Millville, New Jersey, United States
Atlantic City Medical Center
Pomona, New Jersey, United States
Fox Chase Cancer Center at St. Francis Medical Center
Trenton, New Jersey, United States
Ccop - North Shore University Hospital
Manhasset, New York, United States
Herbert Irving Comprehensive Cancer Center at Columbia University
New York, New York, United States
Akron City Hospital
Akron, Ohio, United States
Akron General Medical Center
Akron, Ohio, United States
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, United States
Ccop - Columbus
Columbus, Ohio, United States
Ccop - Dayton
Dayton, Ohio, United States
Ccop - Toledo Community Hospital
Toledo, Ohio, United States
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
Allentown, Pennsylvania, United States
St. Luke'S Hospital Cancer Center
Bethlehem, Pennsylvania, United States
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, United States
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, United States

14 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Luteinizing hormone releasing hormone [LHRH] agonistBicalutamide →Estramustine →Etoposide →Flutamide →Paclitaxel →Warfarin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 2000
Primary completion: 30 Apr 2010
Completion: 30 Nov 2013
Last update posted: 22 Oct 2020
Registered enrollment: 397
Registry id: NCT00004054

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.