Clinical trialNCT00005596CompletedPhase 3Interventional

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

SponsorChildren's Oncology GroupEnrollment1,076Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of chemotherapy is more effective for acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing four regimens of combination chemotherapy to see how well they work in treating children with newly diagnosed acute lymphoblastic leukemia.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Naomi J. Winick, MD
Simmons Cancer Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

123 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Children'S Hospital at Westmead
Westmead, New South Wales, Australia
Royal Children'S Hospital
Brisbane, Queensland, Australia
Royal Children'S Hospital
Parkville, Victoria, Australia

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Cross Cancer Institute
Edmonton, Alberta, Canada
Mcmaster Children'S Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada
Children'S Hospital of Eastern Ontario
Ottawa, Ontario, Canada
Hospital for Sick Children
Toronto, Ontario, Canada
Hopital Sainte Justine
Montreal, Quebec, Canada
Montreal Children'S Hospital at Mcgill University Health Center
Montreal, Quebec, Canada
Centre de Recherche Du Centre Hospitalier de L'Universite Laval
Sainte-Foy, Quebec, Canada

Netherlands

University Medical Center Groningen
Groningen, Netherlands

Puerto Rico

San Jorge Children'S Hospital
Santurce, Puerto Rico

Switzerland

Swiss Pediatric Oncology Group Bern
Bern, Switzerland
Swiss Pediatric Oncology Group Geneva
Geneva, Switzerland

United States

Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham, Alabama, United States
University of South Alabama Cancer Research Institute
Mobile, Alabama, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Stanford Cancer Center at Stanford University Medical Center
Palo Alto, California, United States
Sutter Cancer Center
Sacramento, California, United States
University of California Davis Cancer Center
Sacramento, California, United States
Children'S Hospital and Health Center, San Diego
San Diego, California, United States
Kaiser Permanente Medical Center/kaiser Foundation Hospital - San Diego
San Diego, California, United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States
Yale Comprehensive Cancer Center
New Haven, Connecticut, United States
Broward General Medical Center
Fort Lauderdale, Florida, United States
Children'S Hospital of Southwest Florida
Fort Myers, Florida, United States
University of Florida Shands Cancer Center
Gainesville, Florida, United States
Joe Dimaggio Children'S Hospital at Memorial
Hollywood, Florida, United States
Nemours Children'S Clinic
Jacksonville, Florida, United States
Baptist-South Miami Regional Cancer Program
Miami, Florida, United States
Miami Children'S Hospital
Miami, Florida, United States
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Florida Hospital Cancer Institute
Orlando, Florida, United States
Nemours Children'S Clinic-Orlando
Orlando, Florida, United States
Sacred Heart Children'S Hospital
Pensacola, Florida, United States
All Children'S Hospital
St. Petersburg, Florida, United States
St. Joseph'S Children'S Hospital
Tampa, Florida, United States

83 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CyclophosphamideCytarabineDaunorubicinDexamethasoneLeucovorinMercaptopurineMethotrexatePegaspargaseThioguanineVincristine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2000
Primary completion: 31 Jul 2005
Completion: 31 Jul 2007
Last update posted: 6 Apr 2023
Registered enrollment: 1,076
Registry id: NCT00005596

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.