Clinical trialNCT00006237CompletedPhase 3Interventional

S0008: Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma

SponsorSWOG Cancer Research NetworkEnrollment432Melanoma (Skin)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Interferon alfa may interfere with the growth of cancer cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interleukin-2 may stimulate a person's white blood cells to kill melanoma cells. It is not yet known whether interferon alfa is more effective with or without combination chemotherapy and interleukin-2 for melanoma. PURPOSE: Randomized phase III trial to compare the effectiveness of interferon alfa with or without combination chemotherapy consisting of cisplatin, vinblastine, and dacarbazine, plus interleukin-2, in treating patients who have melanoma.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Alberto S. Pappo, MD
Texas Children's Cancer Center
Principal Investigator
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Frank Haluska, MD, PhD
Massachusetts General Hospital
Study Chair
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John A. Thompson, MD
Seattle Cancer Care Alliance
Principal Investigator
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John M. Kirkwood, MD
University of Pittsburgh
Principal Investigator
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John T. Vetto, MD, FACS
OHSU Knight Cancer Institute
Principal Investigator
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Lawrence E. Flaherty, MD
Barbara Ann Karmanos Cancer Institute
Study Chair
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Michael B. Atkins, MD
Beth Israel Deaconess Medical Center
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

297 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Princess Margaret Hospital for Children
Perth, Western Australia, Australia

United States

Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham
Birmingham, Alabama, United States
Mobile Infirmary Medical Center
Mobile, Alabama, United States
Banner Thunderbird Medical Center
Glendale, Arizona, United States
Banner Good Samaritan Medical Center
Phoenix, Arizona, United States
Ccop - Western Regional, Arizona
Phoenix, Arizona, United States
Phoenix Children'S Hospital
Phoenix, Arizona, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Eden Medical Center
Castro Valley, California, United States
Saint Rose Hospital
Hayward, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Ccop - Bay Area Tumor Institute
Oakland, California, United States
Highland General Hospital
Oakland, California, United States
Valley Care Medical Center
Pleasanton, California, United States
Kaiser Permanente Medical Center - Oakland
Sacramento, California, United States
Scripps Cancer Center - San Diego
San Diego, California, United States
Veterans Affairs Medical Center - San Diego
San Diego, California, United States
Doctors Medical Center - San Pablo Campus
San Pablo, California, United States
Ccop - Santa Rosa Memorial Hospital
Sana Rosa, California, United States
Front Range Cancer Specialists
Fort Collins, Colorado, United States
Poudre Valley Hospital
Fort Collins, Colorado, United States
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
Farmington, Connecticut, United States
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
New Britain, Connecticut, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, United States
Tunnell Cancer Center at Beebe Medical Center
Lewes, Delaware, United States
Ccop - Christiana Care Health Services
Newark, Delaware, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States
All Children'S Hospital
St. Petersburg, Florida, United States
St. Joseph'S Cancer Institute at St. Joseph'S Hospital
Tampa, Florida, United States
Kaplan Cancer Center at St. Mary'S Medical Center
West Palm Beach, Florida, United States
Winship Cancer Institute of Emory University
Altanta, Georgia, United States
Veterans Affairs Medical Center - Atlanta (decatur)
Decatur, Georgia, United States
Pearlman Comprehensive Cancer Center at South Georgia Medical Center
Valdosta, Georgia, United States
Mountain States Tumor Institute at St. Luke'S Regional Medical Center
Boise, Idaho, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, United States
St. Joseph Medical Center
Bloomington, Illinois, United States

257 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CisplatinDacarbazineFilgrastimInterferon alfaInterleukin-2Vinblastine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Aug 2000
Primary completion: 31 Jul 2012
Completion: 31 Jul 2012
Last update posted: 25 Mar 2015
Registered enrollment: 432
Registry id: NCT00006237

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.