Clinical trialNCT00006291CompletedPhase 2Interventional

Safety and Effectiveness of Adding Either an HIV Vaccine, Interleukin-2, or Both to a Patient's Anti-HIV Drug Combination

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment100HIV Infections

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to see if adding an HIV vaccine (ALVAC-HIV vCP1452), IL-2 (interleukin-2, a protein found in the blood that helps boost the immune system), or both to anti-HIV-drug therapy is safe, tolerable, and effective in controlling viral load (level of HIV in the body). (This study has been changed to clarify drug name.) Anti-HIV drugs can help reduce a patient's viral load. However, HIV can still remain in CD4 cells (cells of the immune system that help fight infection). Combining an HIV vaccine, IL-2, or both with anti-HIV drugs may help reduce the number of HIV-infected cells.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Michael Kilby
Study Chair
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Ronald Mitsuyasu
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

26 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico

Puerto Rico-Aids Crs
San Juan, Puerto Rico

United States

Alabama Therapeutics Crs
Birmingham, Alabama, United States
Ucla Care Center Crs
Los Angeles, California, United States
Usc Crs
Los Angeles, California, United States
Stanford Crs
Palo Alto, California, United States
Ucsf Aids Crs
San Francisco, California, United States
Santa Clara Valley Med. Ctr.
San Jose, California, United States
San Mateo County Aids Program
San Mateo, California, United States
Marin County Dept. of Health & Human Services, Hiv/aids Program & Specialty Clinic
San Rafael, California, United States
Harbor-Ucla Med. Ctr. Crs
Torrance, California, United States
University of Colorado Hospital Crs
Aurora, Colorado, United States
Univ. of Miami Aids Crs
Miami, Florida, United States
the Ponce de Leon Ctr. Crs
Atlanta, Georgia, United States
Univ. of Hawaii at Manoa, Leahi Hosp.
Honolulu, Hawaii, United States
Northwestern University Crs
Chicago, Illinois, United States
Indiana Univ. School of Medicine, Infectious Disease Research Clinic
Indianapolis, Indiana, United States
Indiana Univ. School of Medicine, Wishard Memorial
Indianapolis, Indiana, United States
Methodist Hosp. of Indiana
Indianapolis, Indiana, United States
University of Minnesota, Actu
Minneapolis, Minnesota, United States
Beth Israel Med. Ctr., Actu
New York, New York, United States
Ny Univ. Hiv/aids Crs
New York, New York, United States
Univ. of Rochester Actg Crs
Rochester, New York, United States
Unc Aids Crs
Chapel Hill, North Carolina, United States
Hosp. of the Univ. of Pennsylvania Crs
Philadelphia, Pennsylvania, United States
Vanderbilt Therapeutics Crs
Nashville, Tennessee, United States
Univ. of Texas Medical Branch, Actu
Galveston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ALVAC120GNPAldesleukin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: —
Primary completion: —
Completion: 31 Oct 2005
Last update posted: 1 Nov 2021
Registered enrollment: 100
Registry id: NCT00006291

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.