Clinical trialNCT00006392CompletedPhase 3Interventional

S0000 Selenium and Vitamin E in Preventing Prostate Cancer

SponsorSWOG Cancer Research NetworkEnrollment35,533Prostate Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known which regimen of selenium and/or vitamin E may be more effective in preventing prostate cancer. PURPOSE: Randomized phase III trial to determine the effectiveness of selenium and vitamin E, either alone or together, in preventing prostate cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Daniel D Karp, M.D.
Beth Israel Deaconess
Study Chair
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Eric Klein, MD
The Cleveland Clinic
Study Chair
clinicaltrials.gov ↗
Fadlo R. Khuri, M.D.
MD Anderson
Study Chair
clinicaltrials.gov ↗
Ian M. Thompson, M.D.
University of Texas
Study Chair
clinicaltrials.gov ↗
J. Michael Gaziano, M.D.
MAVERIC
Study Chair
clinicaltrials.gov ↗
Laurence H. Klotz, MD
Toronto Sunnybrook Regional Cancer Centre
Study Chair
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Michael M Lieber, M.D.
Mayo Clinic
Study Chair
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Philip J. Walther, MD, PhD
Duke University
Study Chair
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Scott M. Lippman, M.D.
MD Anderson
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States
Midwest Center for Hematology/oncology
Joliet, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, United States
Ccop - Cancer Research for the Ozarks
Springfield, Missouri, United States
St. John'S Regional Health Center
Springfield, Missouri, United States
Bethesda North Hospital
Cincinnati, Ohio, United States
Good Samaritan Hospital Cancer Treatment Center
Cincinnati, Ohio, United States
Tod Children'S Hospital
Youngstown, Ohio, United States
Lafortune Cancer Center at St. John Medical Center
Tulsa, Oklahoma, United States
Geisinger Medical Center
Danville, Pennsylvania, United States
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, United States
U.T. Cancer Institute at University of Tennessee Medical Center
Knoxville, Tennessee, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

SeleniumVitamin E

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jul 2001
Primary completion: 31 May 2011
Completion: 30 Sept 2012
Last update posted: 20 Nov 2015
Registered enrollment: 35,533
Registry id: NCT00006392

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.