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Clinical trialNCT00006400CompletedPhase 3Interventional

Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia

SponsorNational Heart, Lung, and Blood Institute (NHLBI)Enrollment193Anemia, Sickle CellHematologic Diseases
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine if hydroxyurea therapy is effective in the prevention of chronic end organ damage in pediatric patients with sickle cell anemia.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama at Birmingham

    Birmingham, Alabama, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • Howard University

    Washington D.C., District of Columbia, United States

  • University of Miami

    Miami, Florida, United States

  • Emory University School of Medicine

    Atlanta, Georgia, United States

  • Johns Hopkins University

    Baltimore, Maryland, United States

  • Children'S Hospital of Michigan/wayne State Univ.

    Detroit, Michigan, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, United States

  • Suny Health Science Center, Brooklyn

    Brooklyn, New York, United States

  • Duke University Medical Center

    Durham, North Carolina, United States

  • Drexel University

    Philadelphia, Pennsylvania, United States

  • Medical University of South Carolina

    Charleston, South Carolina, United States

  • St. Jude Children'S Research Hospital

    Memphis, Tennessee, United States

  • University of Texas Sw Medical Center

    Dallas, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Aug 2000
Primary completion
30 Sept 2009
Completion
30 Sept 2009
Last update posted
19 Aug 2020
Registered enrollment
193
Registry id
NCT00006400

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.