Clinical trialNCT00008385CompletedPhase 3Interventional

Selenium in Preventing Tumor Growth in Patients With Previously Resected Stage I Non-small Cell Lung Cancer

SponsorECOG-ACRIN Cancer Research GroupEnrollment1,772Lung Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. It is not yet known if selenium is effective in preventing the growth of new tumors in patients with previously resected non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying selenium to see how well it works compared to a placebo in preventing the development of second primary lung tumors in patients who have undergone surgery to remove stage I non-small cell lung cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Daniel D. Karp, MD
M.D. Anderson Cancer Center
Study Chair
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Gerald H. Clamon, MD
Holden Comprehensive Cancer Center
Study Chair
clinicaltrials.gov ↗
Gord Okawara, MD
Margaret and Charles Juravinski Cancer Centre
Study Chair
clinicaltrials.gov ↗
Michael R. Johnston, MD, FRCSC
Nova Scotia Cancer Centre
Study Chair
clinicaltrials.gov ↗
Omer Kucuk, MD
Barbara Ann Karmanos Cancer Institute
Study Chair
clinicaltrials.gov ↗
Randolph S. Marks, MD
Mayo Clinic
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

532 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Tom Baker Cancer Centre - Calgary
Calgary, Alberta, Canada
British Columbia Cancer Agency - Centre for the Southern Interior
Kelowna, British Columbia, Canada
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Saint John Regional Hospital
Saint John, New Brunswick, Canada
Nova Scotia Cancer Centre
Halifax, Nova Scotia, Canada
Northeastern Ontario Regional Cancer Centre
Greater Sudbury, Ontario, Canada
Margaret and Charles Juravinski Cancer Centre
Hamilton, Ontario, Canada
St. Joseph'S Hospital - Charlton Campus
Hamilton, Ontario, Canada
Cancer Centre of Southeastern Ontario at Kingston General Hospital
Kingston, Ontario, Canada
London Regional Cancer Program at London Health Sciences Centre
London, Ontario, Canada
Ottawa Hospital Regional Cancer Centre - General Campus
Ottawa, Ontario, Canada
Algoma District Cancer Program at Sault Area Hospital
Sault Ste. Marie, Ontario, Canada
Cancer Care Program at Thunder Bay Regional Health Sciences
Thunder Bay, Ontario, Canada
Princess Margaret Hospital
Toronto, Ontario, Canada
Trillium Health Centre - Mississauga Site
Toronto, Ontario, Canada
Hopital Notre-Dame Du Chum
Montreal, Quebec, Canada
L'Hopital Laval
Québec, Canada

United States

Mbccop - Gulf Coast
Mobile, Alabama, United States
Providence Cancer Center at Providence Hospital
Mobile, Alabama, United States
Arizona Oncology Services Foundation
Phoenix, Arizona, United States
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn
Scottsdale, Arizona, United States
Virginia G. Piper Cancer Center at Scottsdale Healthcare - Shea
Scottsdale, Arizona, United States
Highlands Oncology Group - Springdale
Bentonville, Arkansas, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
East Bay Radiation Oncology Center
Castro Valley, California, United States
Eden Medical Center
Castro Valley, California, United States
North Bay Cancer Center
Fairfield, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
Los Angeles, California, United States
Contra Costa Regional Medical Center
Martinez, California, United States
Tibotec Therapeutics - Division of Ortho Biotech Products, Lp
Marysville, California, United States
Memorial Medical Center
Modesto, California, United States
El Camino Hospital Cancer Center
Mountain View, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Bay Area Breast Surgeons, Incorporated
Oakland, California, United States
Ccop - Bay Area Tumor Institute
Oakland, California, United States
Highland General Hospital
Oakland, California, United States
Larry G Strieff Md Medical Corporation
Oakland, California, United States
Tom K Lee, Incorporated
Oakland, California, United States

492 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Selenium

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 18 Dec 2000
Primary completion: 30 Jun 2011
Completion: 30 Nov 2019
Last update posted: 5 Jul 2023
Registered enrollment: 1,772
Registry id: NCT00008385

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.