Clinical trialNCT00014118CompletedPhase 2Interventional

Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Larynx or Oropharynx Cancer

SponsorEastern Cooperative Oncology GroupHead and Neck Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by radiation therapy and chemotherapy in treating patients who have stage III or stage IV cancer of the larynx or stage III or stage IV cancer of the oropharynx.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Anthony J. Cmelak, MD
Vanderbilt-Ingram Cancer Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

47 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States
Watson Clinic, Llc
Lakeland, Florida, United States
Hematology and Oncology Associates
Chicago, Illinois, United States
Mercy Hospital and Medical Center
Chicago, Illinois, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States
Ingalls Cancer Care Center at Ingalls Memorial Hospital
Harvey, Illinois, United States
Midwest Center for Hematology/oncology
Joliet, Illinois, United States
Cancer Care and Hematology Specialists of Chicagoland - Niles
Niles, Illinois, United States
Hematology Oncology Associates - Skokie
Skokie, Illinois, United States
Hematology/oncology of the North Shore at Gross Point Medical Center
Skokie, Illinois, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, United States
Siouxland Hematology-Oncology Associates, Llp
Sioux City, Iowa, United States
St. Luke'S Regional Medical Center
Sioux City, Iowa, United States
Cancer Center of Kansas, Pa - Chanute
Chanute, Kansas, United States
Cancer Center of Kansas, Pa - Dodge City
Dodge City, Kansas, United States
Cancer Center of Kansas, Pa - El Dorado
El Dorado, Kansas, United States
Cancer Center of Kansas, Pa - Kingman
Kingman, Kansas, United States
Southwest Medical Center
Liberal, Kansas, United States
Cancer Center of Kansas, Pa - Newton
Newton, Kansas, United States
Cancer Center of Kansas, Pa - Parsons
Parsons, Kansas, United States
Cancer Center of Kansas, Pa - Pratt
Pratt, Kansas, United States
Cancer Center of Kansas, Pa - Salina
Salina, Kansas, United States
Cancer Center of Kansas, Pa - Wellington
Wellington, Kansas, United States
Associates in Womens Health, Pa - North Review
Wichita, Kansas, United States
Ccop - Wichita
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Medical Arts Tower
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Wichita
Wichita, Kansas, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, United States
Wesley Medical Center
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Winfield
Winfield, Kansas, United States
Borgess Medical Center
Kalamazoo, Michigan, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, United States
West Michigan Cancer Center
Kalamazoo, Michigan, United States
Aultman Cancer Center at Aultman Hospital
Canton, Ohio, United States
Metrohealth Cancer Care Center at Metrohealth Medical Center
Cleveland, Ohio, United States
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, United States
Guthrie Cancer Center at Guthrie Clinic Sayre
Sayre, Pennsylvania, United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Morgantown, West Virginia, United States

7 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Paclitaxel →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 6 Jun 2001
Primary completion: 31 Mar 2007
Completion: 31 May 2009
Last update posted: 15 Jun 2023
Registered enrollment: —
Registry id: NCT00014118

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.