Clinical trialNCT00014989CompletedPhase 3Interventional

Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)

SponsorThe George Washington University Biostatistics CenterEnrollment2,136Abruptio PlacentaeCerebral PalsyIntraventricular HemorrhagePeriventricular LeukomalaciaPulmonary Edema

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

As many more premature infants survive, the numbers of these infants with health problems increases. The rate of cerebral palsy (CP) in extremely premature infants is approximately 20%. Magnesium sulfate, the most commonly used drug in the US to stop premature labor, may prevent CP. This trial tests whether magnesium sulfate given to a woman in labor with a premature fetus (24 to 31 weeks out of 40) will reduce the rate of death or moderate to severe CP in the children at 2 years. The children receive ultrasounds of their brains as infants and attend three follow-up visits over two years to assess their health and development.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Dwight Rouse, MD
University of Alabama at Birmingham
Principal Investigator
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Menachem Miodovnik
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Study Director
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

17 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama
Birmingham, Alabama, United States
Dept of Ob/gyn, University of Miami
Miami, Florida, United States
Northwestern University
Chicago, Illinois, United States
Dept of Ob/gyn, Hutzel Hospital
Detroit, Michigan, United States
St. Luke'S - Roosevelt Hospital
New York, New York, United States
University of North Carolina
Chapel Hill, North Carolina, United States
Forsyth Memorial Hospital, Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States
the University Hospital, University of Cincinnati
Cincinnati, Ohio, United States
Case Western University
Cleveland, Ohio, United States
Dept of Ob/gyn, Ohio State University
Columbus, Ohio, United States
Mcp Hahnemann University
Philadelphia, Pennsylvania, United States
Dept of Ob/gyn Magee Womens Hospital
Pittsburgh, Pennsylvania, United States
Women and Infants Hospital
Providence, Rhode Island, United States
Dept of Ob/gyn, Southwestern Medical Center, University of Texas
Dallas, Texas, United States
University of Texas Medical Branch - Galveston
Galveston, Texas, United States
University of Texas - Houston
Houston, Texas, United States
University of Utah Medical Center
Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Magnesium sulfate →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Dec 1997
Primary completion: 28 Feb 2007
Completion: 30 Jun 2007
Last update posted: 12 Jul 2019
Registered enrollment: 2,136
Registry id: NCT00014989

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.