Clinical trialNCT00017147CompletedPhase 3Interventional

S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma

SponsorSWOG Cancer Research NetworkEnrollment183Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. O6-benzylguanine may help carmustine kill more tumor cells by making tumor cells more sensitive to the drug. It is not yet known whether radiation therapy and carmustine are more effective with or without O6-benzylguanine. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy plus carmustine with or without O6-benzylguanine in treating patients who have newly diagnosed glioblastoma multiforme or gliosarcoma.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Alexander M. Spence, MD
University of Washington
Study Chair
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Deborah T. Blumenthal, MD
University of Utah
Study Chair
clinicaltrials.gov ↗
Keith J. Stelzer, MD, PhD
Celilo Cancer Center at Mid-Columbia Medical Center
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

163 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Regional Hospital Cancer Center
Anchorage, Alaska, United States
Banner Good Samaritan Medical Center
Phoenix, Arizona, United States
Banner Thunderbird Medical Center
Phoenix, Arizona, United States
Ccop - Western Regional, Arizona
Phoenix, Arizona, United States
St. Joseph'S Hospital and Medical Center
Phoenix, Arizona, United States
North Bay Cancer Center
Fairfield, California, United States
Memorial Hospital Cancer Center
Colorado Springs, Colorado, United States
St. Anthony Central Hospital
Denver, Colorado, United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center
Denver, Colorado, United States
North Colorado Medical Center
Greeley, Colorado, United States
Mckee Medical Center
Loveland, Colorado, United States
St. Anthony North Hospital
Westminster, Colorado, United States
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola
Pensacola, Florida, United States
Ccop - Atlanta Regional
Atlanta, Georgia, United States
Northside Hospital Cancer Center
Atlanta, Georgia, United States
Piedmont Hospital
Atlanta, Georgia, United States
Saint Joseph'S Hospital of Atlanta
Atlanta, Georgia, United States
Wellstar Cobb Hospital
Austell, Georgia, United States
Charles B. Eberhart Cancer Center at Dekalb Medical Center
Decatur, Georgia, United States
Northeast Georgia Medical Center
Gainesville, Georgia, United States
Gwinnett Medical Center
Lawrenceville, Georgia, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital
Marietta, Georgia, United States
Southern Regional Medical Center
Riverdale, Georgia, United States
Hematology Oncology Associates of Eastern Idaho
Idaho Falls, Idaho, United States
Saint Anthony'S Hospital at Saint Anthony'S Health Center
Alton, Illinois, United States
University of Illinois at Chicago Cancer Center
Chicago, Illinois, United States
Veterans Affairs Medical Center - Chicago Westside Hospital
Chicago, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States
Good Samaritan Regional Health Center
Mount Vernon, Illinois, United States
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, United States
St. Francis Hospital and Health Centers
Beech Grove, Indiana, United States
Genesis Medical Center - West Campus
Davenport, Iowa, United States
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, United States
Cancer Center of Kansas - Chanute
Chanute, Kansas, United States
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, United States
Cancer Center of Kansas, P.A. - El Dorado
El Dorado, Kansas, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Kansas, United States
Cancer Center of Kansas - Kingman
Kingman, Kansas, United States

123 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

6-O-benzylguanineCarmustine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2001
Primary completion: 31 May 2006
Completion: 30 Nov 2012
Last update posted: 30 Jan 2013
Registered enrollment: 183
Registry id: NCT00017147

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.