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Clinical trialNCT00017511CompletedPhase 3Interventional

Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer

SponsorDaiichi SankyoHead and Neck CancerOral ComplicationsRadiation Toxicity
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Cevimeline may be effective in treating dry mouth that is caused by radiation therapy for head and neck cancer. It is not yet known if cevimeline is more effective than no therapy in treating dry mouth caused by radiation therapy. PURPOSE: Randomized phase III trial to determine the effectiveness of cevimeline in treating patients who have dryness of the mouth caused by radiation therapy for head and neck cancer.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

71 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama at Birmingham Comprehensive Cancer Center

    Birmingham, Alabama, United States

  • Mobile Infirmary Medical Center

    Mobile, Alabama, United States

  • Cranial Pain Research

    Tucson, Arizona, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, United States

  • Alta Bates Comprehensive Cancer Center

    Berkeley, California, United States

  • Jonsson Comprehensive Cancer Center, Ucla

    Los Angeles, California, United States

  • Chao Family Comprehensive Cancer Center

    Orange, California, United States

  • Radiation Oncology Center - Sacramento

    Sacramento, California, United States

  • Rebecca and John Moores Ucsd Cancer Center

    San Diego, California, United States

  • Stanford University Medical Center

    Stanford, California, United States

  • Colorado Otolaryngology Associates

    Colorado Springs, Colorado, United States

  • University of Connecticut Health Center

    Farmington, Connecticut, United States

  • Walter Reed Army Medical Center

    Washington D.C., District of Columbia, United States

  • Innovative Medical Research of South Florida, Inc.

    Miami, Florida, United States

  • Medical College of Georgia Hospital and Clinics

    Augusta, Georgia, United States

  • Kootenai Medical Center

    Coeur d'Alene, Idaho, United States

  • University of Chicago Cancer Research Center

    Chicago, Illinois, United States

  • University of Illinois at Chicago

    Chicago, Illinois, United States

  • Evanston Northwestern Health Care

    Evanston, Illinois, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, United States

  • Central Baptist Hospital

    Lexington, Kentucky, United States

  • James Graham Brown Cancer Center

    Louisville, Kentucky, United States

  • Facility name not stated

    Louisville, Kentucky, United States

  • Tulane Cancer Center

    New Orleans, Louisiana, United States

  • Harbor Hospital Center

    Baltimore, Maryland, United States

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Baltimore, Maryland, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, United States

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, United States

  • Ear, Nose, and Throat Specialty Care of Minnesota, P.A.

    Minneapolis, Minnesota, United States

  • University of Minnesota School of Dentistry

    Minneapolis, Minnesota, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, United States

  • University of Missouri

    Columbia, Missouri, United States

  • Siteman Cancer Center

    St Louis, Missouri, United States

  • University of Nebraska Medical Center

    Lincoln, Nebraska, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, United States

  • Norris Cotton Cancer Center

    Lebanon, New Hampshire, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, United States

  • Monmouth Medical Center

    Long Branch, New Jersey, United States

  • Professional Otolaryngology Associates

    Voorhees Township, New Jersey, United States

  • North Shore University Hospital

    Manhasset, New York, United States

31 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Jun 2001
Primary completion
31 Mar 2003
Completion
31 Mar 2003
Last update posted
16 May 2012
Registered enrollment
—
Registry id
NCT00017511

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.