Clinical trialNCT00023660CompletedPhase 1/PHASE2Interventional

Radiation Therapy Plus Celecoxib, Fluorouracil, and Cisplatin in Patients With Locally Advanced Cervical Cancer

SponsorRadiation Therapy Oncology GroupEnrollment84Cervical Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy in different ways and combining it with chemotherapy may kill more tumor cells. Celecoxib may slow the growth of cervical cancer by stopping blood flow to the tumor. PURPOSE: Phase I/II trial to study the effectiveness of radiation therapy plus celecoxib, fluorouracil, and cisplatin in treating patients who have locally advanced cervical cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David K. Gaffney, MD, PhD
University of Utah
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

36 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mobile Infirmary Medical Center
Mobile, Alabama, United States
Foundation for Cancer Research and Education
Phoenix, Arizona, United States
Mills-Peninsula Health Services
Burlingame, California, United States
Sutter Health Western Division Cancer Research Group
Greenbrae, California, United States
Ucsf Comprehensive Cancer Center
San Francisco, California, United States
Memorial Hospital Cancer Center
Colorado Springs, Colorado, United States
Baptist Hospital of Miami
Miami, Florida, United States
Regional Radiation Oncology Center at Rome
Rome, Georgia, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Ball Memorial Hospital Cancer Center
Muncie, Indiana, United States
West Michigan Cancer Center
Kalamazoo, Michigan, United States
Ccop - Kansas City
Kansas City, Missouri, United States
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
Omaha, Nebraska, United States
Ccop - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, United States
Monmouth Medical Center
Long Branch, New Jersey, United States
South Jersey Regional Cancer Center
Millville, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital
Mount Holly, New Jersey, United States
Newark Beth Israel Medical Center
Newark, New Jersey, United States
Community Medical Center
Toms River, New Jersey, United States
New York Methodist Hospital
Brooklyn, New York, United States
State University of New York Health Science Center at Brooklyn
Brooklyn, New York, United States
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, United States
Akron City Hospital - Summa Health System
Akron, Ohio, United States
Akron General Medical Center
Akron, Ohio, United States
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, United States
Mercy Fitzgerald Hospital
Darby, Pennsylvania, United States
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, United States
Paoli Memorial Hospital
Paoli, Pennsylvania, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, United States
Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, United States
Ccop - Mainline Health
Wynnewood, Pennsylvania, United States
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, United States
University of Texas - Md Anderson Cancer Center
Houston, Texas, United States
Lds Hospital
Salt Lake City, Utah, United States
Dixie Regional Medical Center
St. George, Utah, United States
Ccop - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Celecoxib →Cisplatin →Fluorouracil →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Aug 2001
Primary completion: 31 Jan 2005
Completion: —
Last update posted: 19 Nov 2013
Registered enrollment: 84
Registry id: NCT00023660

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.