Clinical trialNCT00026286CompletedPhase 3Interventional

Hormone Replacement Therapy for Hot Flashes and/or Vaginal Symptoms in Postmenopausal Women Receiving Tamoxifen for Breast Cancer

SponsorEastern Cooperative Oncology GroupBreast CancerHot FlashesMenopausal Symptoms

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Hormone replacement therapy may be effective in managing the hot flashes and/or vaginal symptoms in postmenopausal women who are receiving tamoxifen for breast cancer. PURPOSE: Randomized phase III trial to determine the effectiveness of hormone replacement therapy in managing hot flashes and/or vaginal symptoms in postmenopausal women who are receiving tamoxifen for breast cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Melody A. Cobleigh, MD
Rush University Medical Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

24 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, United States
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, United States
Ccop - Central Illinois
Decatur, Illinois, United States
Ccop - Carle Cancer Center
Urbana, Illinois, United States
Indiana University Cancer Center
Indianapolis, Indiana, United States
Veterans Affairs Medical Center - Indianapolis (roudebush)
Indianapolis, Indiana, United States
Ccop - Wichita
Wichita, Kansas, United States
Ccop - Ann Arbor Regional
Ann Arbor, Michigan, United States
Ccop - Kalamazoo
Kalamazoo, Michigan, United States
Ccop - Metro-Minnesota
Saint Louis Park, Minnesota, United States
Ccop - Missouri Valley Cancer Consortium
Omaha, Nebraska, United States
Ccop - Northern New Jersey
Hackensack, New Jersey, United States
Albert Einstein Comprehensive Cancer Center
The Bronx, New York, United States
Ccop - Merit Care Hospital
Fargo, North Dakota, United States
Ireland Cancer Center
Cleveland, Ohio, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States
University of Pennsylvania Cancer Center
Philadelphia, Pennsylvania, United States
Ccop - Mainline Health
Wynnewood, Pennsylvania, United States
Ccop - Sioux Community Cancer Consortium
Sioux Falls, South Dakota, United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
Veterans Affairs Medical Center - Tennessee Valley Healthcare System - Nashville Campus
Nashville, Tennessee, United States
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States
Veterans Affairs Medical Center - Madison
Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Estrogens, conjugated (USP)Medroxyprogesterone →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 Nov 2000
Primary completion: 31 Aug 2002
Completion: 15 Jun 2007
Last update posted: 15 Jun 2023
Registered enrollment: —
Registry id: NCT00026286

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.