Clinical trialNCT00027859CompletedPhase 3Interventional

Hormone Therapy Compared With Combination Chemotherapy in Treating Patients With Prostate Cancer

SponsorEastern Cooperative Oncology GroupProstate Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as ketoconazole may stop the production of androgens. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy is more effective than combination chemotherapy in treating prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy with that of combination chemotherapy in treating patients who have prostate cancer that has been previously treated with androgen suppression.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Gregory P. Swanson, MD
Deaconess Medical Center, Spokane, Washington
Study Chair
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Michael A. Carducci, MD
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study ChairKOL profile →
clinicaltrials.gov ↗
Nirmala Bhoopalam, MD
Veterans Affairs Medical Center - Hines
Study Chair
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William Dahut, MD
National Cancer Institute (NCI)
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

98 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Comprehensive Cancer Institute
Huntsville, Alabama, United States
Ccop - Mayo Clinic Scottsdale Oncology Program
Scottsdale, Arizona, United States
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, United States
Veterans Affairs Medical Center - Little Rock
Little Rock, Arkansas, United States
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
Los Angeles, California, United States
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, United States
Naval Medical Center - San Diego
San Diego, California, United States
Ucsf Comprehensive Cancer Center
San Francisco, California, United States
Medical Center of Aurora - South Campus
Aurora, Colorado, United States
Boulder Community Hospital
Boulder, Colorado, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, United States
Ccop - Colorado Cancer Research Program, Incorporated
Denver, Colorado, United States
Porter Adventist Hospital
Denver, Colorado, United States
Presbyterian - St. Luke'S Medical Center
Denver, Colorado, United States
Rocky Mountain Cancer Centers - Denver Rose
Denver, Colorado, United States
St. Joseph Hospital
Denver, Colorado, United States
Veterans Affairs Medical Center - Denver
Denver, Colorado, United States
Swedish Medical Center
Englewood, Colorado, United States
Sky Ridge Medical Center
Lone Tree, Colorado, United States
Hope Cancer Care Center at Longmont United Hospital
Longmont, Colorado, United States
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, United States
Rocky Mountain Cancer Centers - Thornton
Thornton, Colorado, United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, United States
Memorial Regional Cancer Center at Memorial Regional Hospital
Hollywood, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
Tampa, Florida, United States
Veterans Affairs Medical Center - Tampa (haley)
Tampa, Florida, United States
Veterans Affairs Medical Center - Atlanta (decatur)
Decatur, Georgia, United States
Mbccop - Hawaii
Honolulu, Hawaii, United States
University of Chicago Cancer Research Center
Chicago, Illinois, United States
Ccop - Central Illinois
Decatur, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States
Veterans Affairs Medical Center - Hines
Hines, Illinois, United States
Ccop - Illinois Oncology Research Association
Peoria, Illinois, United States
West Suburban Center for Cancer Care
River Forest, Illinois, United States
Ccop - Carle Cancer Center
Urbana, Illinois, United States
Indiana University Cancer Center
Indianapolis, Indiana, United States
Veterans Affairs Medical Center - Indianapolis (roudebush)
Indianapolis, Indiana, United States
Ccop - Cedar Rapids Oncology Project
Cedar Rapids, Iowa, United States

58 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Docetaxel →Estramustine →Ketoconazole →Therapeutic hydrocortisone

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Oct 2003
Primary completion: 31 Dec 2004
Completion: —
Last update posted: 15 Jun 2023
Registered enrollment: —
Registry id: NCT00027859

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.