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Clinical trialNCT00028366CompletedInterventional

Dual Versus Triple Protease Inhibitor Combinations, Including Ritonavir, in HIV Infected People

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment56HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Ritonavir (RTV) is a protease inhibitor (PI) commonly used to increase drug levels of other PIs in HIV drug treatment. The purpose of this study is to compare a combination of drugs which includes RTV and 2 protease inhibitors (PIs) with 2 combinations that include RTV and another PI. This study also will compare the effectiveness, safety, tolerability, and drug levels in the blood of these anti-HIV drug combinations.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Usc Crs

    Los Angeles, California, United States

  • Ucsf Aids Crs

    San Francisco, California, United States

  • the Ponce de Leon Ctr. Crs

    Atlanta, Georgia, United States

  • Indiana Univ. School of Medicine, Infectious Disease Research Clinic

    Indianapolis, Indiana, United States

  • Indiana Univ. School of Medicine, Wishard Memorial

    Indianapolis, Indiana, United States

  • Methodist Hosp. of Indiana

    Indianapolis, Indiana, United States

  • Hiv Prevention & Treatment Crs

    New York, New York, United States

  • Univ. of Cincinnati Crs

    Cincinnati, Ohio, United States

  • Case Crs

    Cleveland, Ohio, United States

  • Metrohealth Crs

    Cleveland, Ohio, United States

  • the Ohio State Univ. Aids Crs

    Columbus, Ohio, United States

  • Vanderbilt Therapeutics Crs

    Nashville, Tennessee, United States

  • University of Washington Aids Crs

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Fosamprenavir →Lopinavir →Ritonavir →Tenofovir disoproxil →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
—
Primary completion
—
Completion
31 Jul 2005
Last update posted
1 Nov 2021
Registered enrollment
56
Registry id
NCT00028366
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.