Clinical trialNCT00041938CompletedPhase 3Interventional

Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial

SponsorColumbia UniversityEnrollment2,305Heart DiseaseIschemic Heart DiseaseMyocardial InfarctionStroke

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine which of two treatments, Warfarin or aspirin, is better for preventing death and stroke in patients with poor heart function. We are now transitioning into the sub-analysis part of the WARCEF patient data. The study has recently completed data analysis for its Primary Aim. All randomized patients have completed their follow up. All study related procedure as per the protocol has been completed. We are now in the extension phase of the study to obtain more patient data to address further aims of the study. No new procedures are performed and data already in place at the sites will be collected (EKG and echocardiograms). The aims for this study extension are: * To assess progression of cardiac dysfunction over time among heart failure patients * To correlate prognosis with cardiac dysfunction

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Seamus Thompson, PhD
Statistical PI: Clinical Professor of Biostatistics and Neurology
Principal Investigator
clinicaltrials.gov ↗
Shunichi Homma, M.D.
Principal Cardiologist, Associate Chief, Division of Cardiology, and Director, Echocardiography Laboratories Professor of Medicine
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

64 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Center for Neurologic Research
Lethbridge, Alberta, Canada
St. Boniface General Hospital
Winnipeg, Manitoba, Canada
Saint John Regional Hospital
Saint John, New Brunswick, Canada
Qe Ii Health Sciences Centre
Halifax, Nova Scotia, Canada
London Health Sciences Centre
London, Ontario, Canada
Ottawa Heart Institute
Ottawa, Ontario, Canada
Etobicoke Cardiac Research Centre
Rexdale, Ontario, Canada
St. Michael'S Hospital
Toronto, Ontario, Canada
Montreal General Hospital
Montreal, Quebec, Canada
Montreal Heart Institute
Montreal, Quebec, Canada

United States

Southern Arizona Veterans Affairs Medical Center
Tucson, Arizona, United States
University of Arizona Health Sciences Center
Tucson, Arizona, United States
Santa Clara Medical Center
Santa Clara, California, United States
West Los Angeles Veterans Affairs Medical Center
West Los Angeles, California, United States
Denver Health Medical Center
Denver, Colorado, United States
Denver Veterans Affairs Medical Center
Denver, Colorado, United States
George Washington University
Washington D.C., District of Columbia, United States
Mayo Clinic Transplant Center
Jacksonville, Florida, United States
Melbourne Internal Medicine Associates
Melbourne, Florida, United States
Jackson Memorial Hospital/u. of Miami
Miami, Florida, United States
Mercy Research Institute
Miami, Florida, United States
Cardiovascular Consultants of South Florida
Tamarac, Florida, United States
Morehouse School of Medicine
Atlanta, Georgia, United States
Northeast Georgia Heart Center
Gainesville, Georgia, United States
University of Illinois at Chicago
Chicago, Illinois, United States
Methodist Heart, Lung and Vascular Institute
Peoria, Illinois, United States
University of Kentucky
Lexington, Kentucky, United States
Louisville Veterans Affairs Medical Center
Louisville, Kentucky, United States
University of Louisville
Louisville, Kentucky, United States
Gulf Regional Research, Llc
Metairie, Louisiana, United States
Lsu Health Sciences Center
Shreveport, Louisiana, United States
Lahey Clinic
Burlington, Massachusetts, United States
Veterans Affairs Medical Center
Detroit, Michigan, United States
Mercy Health Partners
Muskegon, Michigan, United States
Reno Veterans Affairs Medical Center
Reno, Nevada, United States
Concord Hospital
Concord, New Hampshire, United States
Umdnj - New Brunswick
New Brunswick, New Jersey, United States
University of Medicine and Dentistry of New Jersey
Newark, New Jersey, United States
Albany Medical College
Albany, New York, United States
Buffalo General Hospital
Buffalo, New York, United States

24 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Warfarin →Aspirin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 2002
Primary completion: 31 Aug 2011
Completion: 31 Jul 2014
Last update posted: 5 Sept 2014
Registered enrollment: 2,305
Registry id: NCT00041938

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.