Clinical trialNCT00045968UnknownPhase 3Interventional

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer

SponsorNorthwest BiotherapeuticsEnrollment348Brain CancerBrain TumorGBMGlioblastomaGlioblastoma MultiformeGlioma+1 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM for whom surgery is indicated. Patients must enter screening at a participating site prior to surgical resection of the tumor. Patients will receive the standard of care, including radiation and Temodar therapy and two out of three will additionally receive DCVax-L, with the remaining one third receiving a placebo. All patients will have the option to receive DCVax-L in a crossover arm upon documented disease progression. (note: DCVax-L when used for patients with brain cancer is sometimes also referred to as DCVax-Brain)

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Linda Liau, M.D.
University of California, Los Angeles
Principal Investigator
clinicaltrials.gov ↗
Marnix L. Bosch, MBA, PhD
Northwest Biotherapeutics
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

86 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Montreal Neurological Institute, Mcgill University
Montreal, Quebec, Canada
Chus - Hôpital Fleurimont
Sherbrooke, Quebec, Canada

Germany

Universitätsklinikum Heidelberg Neurochirurgische Klinik
Heidelberg, Baden-Wurttemberg, Germany
Katharinenhospital
Stuttgart, Baden-Wurttemberg, Germany
Universitätsklinikum Frankfurtklinik Und Poliklinik Für Neurochirurgie
Frankfurt am Main, Hesse, Germany
Universitätsklinikum Bonn Nervenklinik (zentrum), Klinik Und Poliklinik Für Neurochirurgie
Bonn, North Rhine-Westphalia, Germany
Universitätsklinikum Klinik Für Allgemeine Neurochirurgie
Cologne, North Rhine-Westphalia, Germany
Klinik Für Neurochirurgie, Klinikum Chemnitz Ggmbh
Chemnitz, Saxony, Germany
Universitätsklinikum Carl Gustav Carus An Der Technischen Universität Dresden
Dresden, Saxony, Germany
Bg-Kliniken Bergmannstrost, Klinik Für Neurochirurgie
Halle, Saxony-Anhalt, Germany
Neurochirurgische Klinik
Hamburg, Germany

United Kingdom

Addenbrookes Nhs Trust
Cambridge, Cambridgeshire, East Anglia, United Kingdom
Kings College Hosital Nhs Foundation Trust
London, Greater London, United Kingdom
University College Hospital London
London, Greater London, United Kingdom
University Hospital of Birmingham Nhs Foundation Trust
Birmingham, West Midlands, United Kingdom

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Sutter East Bay Neuroscience Institute-Eden Medical Center
Castro Valley, California, United States
City of Hope
Duarte, California, United States
Ucsd Moores Cancer Center
La Jolla, California, United States
Kaiser Permanente - Los Angeles
Los Angeles, California, United States
Ucla Medical Center
Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States
St. Joseph Hospital of Orange
Orange, California, United States
University of California, Irvine Medical Center
Orange, California, United States
Kaiser Permanente - Redwood City
Redwood City, California, United States
Sutter Institute for Medical Research
Sacramento, California, United States
University of Colorado Cancer Center
Aurora, Colorado, United States
Colorado Neurological Institute
Englewood, Colorado, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
University of Florida
Gainesville, Florida, United States
Memorial Cancer Institute
Hollywood, Florida, United States
Mount Sinai Community Clinical Oncology Program
Miami Beach, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
Piedmont Atlanta Hospital
Atlanta, Georgia, United States
Rush University Medical Center
Chicago, Illinois, United States
Illinois Cancer Care
Peoria, Illinois, United States
Cadence Cancer Center
Warrenville, Illinois, United States
Iu Simon Cancer Center
Indianapolis, Indiana, United States
University of Kansas Cancer Center
Westwood, Kansas, United States

46 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Dendritic cell immunotherapy

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Dec 2006
Primary completion: 30 Nov 2022
Completion: —
Last update posted: 18 May 2022
Registered enrollment: 348
Registry id: NCT00045968

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.