Clinical trialNCT00062426CompletedPhase 3Interventional

Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer

SponsorPrologue Research InternationalColorectal Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, fluorouracil, leucovorin, and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different combinations may kill more tumor cells. Monoclonal antibodies, such as bevacizumab (Avastin™), can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substances to them. It is not yet known which regimen works better in treating advanced colorectal cancer. PURPOSE: This randomized phase III trial is to see if oxaliplatin and bevacizumab work better when combined with either fluorouracil and leucovorin or capecitabine in treating patients who have metastatic or recurrent colorectal cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Lauri Welles, MD
Sanofi-Synthelabo
clinicaltrials.gov ↗
Richard A. Gams, MD
Prologue Research International
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

52 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States
Arizona Clinical Research Center
Tucson, Arizona, United States
California Cancer Care, Inc.
Greenbrae, California, United States
Valley Tumor Medical Group
Lancaster, California, United States
Cancer and Blood Institute of the Desert
Rancho Mirage, California, United States
Rocky Mountain Cancer Centers - Midtown
Denver, Colorado, United States
Northwestern Connecticut Oncology-Hematology Associates
Torrington, Connecticut, United States
Lombardi Cancer Center at Georgetown University Medical Center
Washington D.C., District of Columbia, United States
Lynn Regional Cancer Center West
Boca Raton, Florida, United States
Florida Cancer Specialists
Fort Myers, Florida, United States
Florida Oncology Associates
Jacksonville, Florida, United States
Hematology and Oncology Consultants, P.A.
Orlando, Florida, United States
Hematology Oncology Associates of Thetreasure Coast - Port St. Lucie
Port Saint Lucie, Florida, United States
Palm Beach Cancer Institute
West Palm Beach, Florida, United States
Peachtree Hematology and Oncology Consultants, P.C.
Atlanta, Georgia, United States
North Idaho Cancer Center
Coeur d'Alene, Idaho, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States
Lutheran General Cancer Care Center
Park Ridge, Illinois, United States
West Suburban Center for Cancer Care
River Forest, Illinois, United States
Saint Anthony Medical Center
Rockford, Illinois, United States
Ccop - Northern Indiana Cr Consortium
South Bend, Indiana, United States
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, United States
Ccop - Wichita
Wichita, Kansas, United States
Greater Baltimore Medical Center and Cancer Center
Baltimore, Maryland, United States
Jackson Oncology Associates, Pllc
Jackson, Mississippi, United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, United States
Deaconess Billings Clinic Cancer Center
Billings, Montana, United States
Cooper Cancer Institute at Cooper University Hospital
Voorhees Township, New Jersey, United States
Advanced Oncology Associates
Armonk, New York, United States
North Shore Hematology/oncology Associates, P.C.
East Setauket, New York, United States
Arena Oncology Associates
Great Neck, New York, United States
New York University Medical Center
New York, New York, United States
St. Vincents Comprehensive Cancer Center
New York, New York, United States
New York Medical College
Valhalla, New York, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, United States
Southeastern Medical Oncology Center
Goldsboro, North Carolina, United States
Physicians East - Quadrangle
Greenville, North Carolina, United States
Raleigh Hematology/oncology Associates, P.A. - Wake Practice
Raleigh, North Carolina, United States
Hematology Oncology Consultants Inc
Columbus, Ohio, United States
Hematology/oncology of Salem
Salem, Oregon, United States

12 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bevacizumab →Capecitabine →Fluorouracil →Leucovorin →Oxaliplatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 May 2003
Primary completion: —
Completion: 28 Feb 2011
Last update posted: 6 Nov 2013
Registered enrollment: —
Registry id: NCT00062426

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.