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Clinical trialNCT00068601CompletedPhase 3Interventional

S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer

SponsorSWOG Cancer Research NetworkEnrollment257Breast CancerInfertilityMenopausal Symptoms
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Goserelin blocks hormone production in the ovaries. It is not yet known whether ovarian suppression using goserelin will prevent ovarian failure (early menopause) in women receiving chemotherapy for breast cancer. PURPOSE: This randomized phase III trial is studying how well giving goserelin together with chemotherapy works compared with chemotherapy alone in preventing early menopause in women with stage I, stage II, or stage IIIA breast cancer.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

34 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Mater Hospital - North Sydney

    North Sydney, New South Wales, Australia

  • Royal North Shore Hospital

    St Leonards, New South Wales, Australia

  • Newcastle Mater Misericordiae Hospital

    Waratah, New South Wales, Australia

  • Royal Adelaide Hospital Cancer Centre

    Adelaide, South Australia, Australia

  • Flinders Medical Centre

    Bedford Park, South Australia, Australia

  • Royal Hobart Hospital

    Hobart, Tasmania, Australia

  • Ballarat Oncology and Haematology Services

    Ballarat, Victoria, Australia

  • Box Hill Hospital

    Box Hill, Victoria, Australia

  • Monash Medical Center - Clayton Campus

    Clayton, Victoria, Australia

  • Peter Maccallum Cancer Centre

    East Melbourne, Victoria, Australia

  • Maroondah Hospital

    East Ringwood, Victoria, Australia

  • St. Vincent'S Hospital - Melbourne

    Fitzroy, Victoria, Australia

  • Royal Melbourne Hospital

    Parkville, Victoria, Australia

  • Royal Perth Hospital

    Perth, Western Australia, Australia

Belgium
  • Centre Hospitalier Hutois

    Huy, Belgium

  • U.Z. Gasthuisberg

    Leuven, Belgium

  • Chu Liege - Domaine Universitaire Du Sart Tilman

    Liège, Belgium

  • Centre Hospitalier Regional de la Citadelle

    Liège, Belgium

  • Az Damiaan

    Ostend, Belgium

  • Centre Hospitalier Peltzer-la Tourelle

    Verviers, Belgium

Hungary
  • National Institute of Oncology

    Budapest, Hungary

Italy
  • Ospedali Riuniti Di Bergamo

    Bergamo, Italy

  • Ospedale Degli Infermi - Asl 12

    Biella, Italy

  • Ospedale Civile Ramazzini

    Carpi, Italy

  • Ospedale Alessandro Manzoni

    Lecco, Italy

  • European Institute of Oncology

    Milan, Italy

New Zealand
  • Auckland City Hospital

    Auckland, New Zealand

Switzerland
  • Oncology Institute of Southern Switzerland

    Bellinzona, Switzerland

  • Inselspital Bern

    Bern, Switzerland

  • Centre Hospitalier Universitaire Vaudois

    Lausanne, Switzerland

  • Oncology Institute of Southern Switzerland - Locarno

    Locarno, Switzerland

  • Oncology Institute of Southern Switzerland - Lugano

    Lugano, Switzerland

  • Oncology Institute of Southern Switzerland - Mendrisio

    Mendrisio, Switzerland

  • Regionalspital

    Thun, Switzerland

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Oct 2003
Primary completion
31 Jan 2014
Completion
30 Sept 2016
Last update posted
30 Dec 2019
Registered enrollment
257
Registry id
NCT00068601

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.