Clinical trialNCT00070018CompletedPhase 2Interventional

S0313 Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, and Radiation Therapy Followed By Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Stage I or Stage II Non-Hodgkin's Lymphoma

SponsorSWOG Cancer Research NetworkEnrollment46Lymphoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Monoclonal antibodies, such as rituximab and yttrium Y 90 ibritumomab tiuxetan, can locate cancer cells and either kill them or deliver radioactive cancer-killing substances to them without harming normal cells. Combining chemotherapy with radiation therapy and monoclonal antibody therapy may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with radiation therapy and monoclonal antibody therapy works in treating patients with stage I or stage II non-Hodgkin's lymphoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Baldassarre D. Stea, MD, PhD
University of Arizona
Study Chair
clinicaltrials.gov ↗
Louis S. Constine, MD
James P. Wilmot Cancer Center
Study Chair
clinicaltrials.gov ↗
Oliver W. Press, MD, PhD
Fred Hutchinson Cancer Center
Study Chair
clinicaltrials.gov ↗
Thomas P. Miller, MD
University of Arizona
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

48 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Regional Hospital Cancer Center
Anchorage, Alaska, United States
Providence Cancer Center
Anchorage, Alaska, United States
Providence Saint Joseph Medical Center - Burbank
Burbank, California, United States
Mountain States Tumor Institute at St. Luke'S Regional Medical Center
Boise, Idaho, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, United States
Edward Hospital Cancer Center
Naperville, Illinois, United States
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, United States
Cancer Center of Kansas, Pa - Chanute
Chanute, Kansas, United States
Cancer Center of Kansas, Pa - Dodge City
Dodge City, Kansas, United States
Cancer Center of Kansas, Pa - El Dorado
El Dorado, Kansas, United States
Cancer Center of Kansas-Independence
Independence, Kansas, United States
Cancer Center of Kansas, Pa - Kingman
Kingman, Kansas, United States
Southwest Medical Center
Liberal, Kansas, United States
Cancer Center of Kansas, Pa - Newton
Newton, Kansas, United States
Cancer Center of Kansas, Pa - Parsons
Parsons, Kansas, United States
Cancer Center of Kansas, Pa - Pratt
Pratt, Kansas, United States
Cancer Center of Kansas, Pa - Salina
Salina, Kansas, United States
Cotton-O'Neil Cancer Center
Topeka, Kansas, United States
Cancer Center of Kansas, Pa - Wellington
Wellington, Kansas, United States
Associates in Womens Health, Pa - North Review
Wichita, Kansas, United States
Ccop - Wichita
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Medical Arts Tower
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Wichita
Wichita, Kansas, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, United States
Wesley Medical Center
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Winfield
Winfield, Kansas, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, United States
Mecosta County Medical Center
Big Rapids, Michigan, United States
Butterworth Hospital at Spectrum Health
Grand Rapids, Michigan, United States
Ccop - Grand Rapids
Grand Rapids, Michigan, United States
Lacks Cancer Center at Saint Mary'S Health Care
Grand Rapids, Michigan, United States
Hackley Hospital
Muskegon, Michigan, United States
Providence Cancer Institute at Providence Hospital - Southfield Campus
Southfield, Michigan, United States
Munson Medical Center
Traverse City, Michigan, United States
Metro Health Hospital
Wyoming, Michigan, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States
Mcdowell Cancer Center at Akron General Medical Center
Akron, Ohio, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States

8 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cyclophosphamide →Indium-111 ibritumomab tiuxetanYttrium-90 ibritumomab tiuxetanDoxorubicin →Prednisone →Rituximab →Vincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Feb 2004
Primary completion: 30 Nov 2010
Completion: 8 Jan 2015
Last update posted: 11 Jan 2022
Registered enrollment: 46
Registry id: NCT00070018

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.