Clinical trialNCT00070447CompletedPhase 2Interventional

Rituximab, Prednisone, Cyclophosphamide, Doxorubicin, Vincristine, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Previously Untreated Mantle Cell Lymphoma

SponsorNational Cancer Institute (NCI)Lymphoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Monoclonal antibodies, such as rituximab and yttrium Y 90 ibritumomab tiuxetan, can locate cancer cells and either kill them or deliver radioactive cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy, such as prednisone, cyclophosphamide, doxorubicin, and vincristine, use different ways to stop cancer cells from dividing so they stop growing or die. Combining monoclonal antibody therapy with chemotherapy may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving rituximab and combination chemotherapy together with yttrium Y 90 ibritumomab tiuxetan works in treating patients with previously untreated mantle cell lymphoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Leo I. Gordon, MD
Robert H. Lurie Cancer Center
clinicaltrials.gov ↗
Mitchell R. Smith, MD, PhD
Fox Chase Cancer Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

87 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Westmead Hospital
Westmead, New South Wales, Australia

Peru

Instituto de Enfermedades Neoplasicas
Lima, Peru

Puerto Rico

Mbccop - San Juan
San Juan, Puerto Rico
San Juan City Hospital
San Juan, Puerto Rico
Veterans Affairs Medical Center - San Juan
San Juan, Puerto Rico

South Africa

Pretoria Academic Hospital
Pretoria, South Africa

United States

Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham, Alabama, United States
Ccop - Mayo Clinic Scottsdale Oncology Program
Scottsdale, Arizona, United States
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Veterans Affairs Medical Center - Palo Alto
Palo Alto, California, United States
Stanford Cancer Center at Stanford University Medical Center
Stanford, California, United States
Ccop - Colorado Cancer Research Program, Incorporated
Denver, Colorado, United States
Ccop - Christiana Care Health Services
Newark, Delaware, United States
Mbccop - Howard University Cancer Center
Washington D.C., District of Columbia, United States
Veterans Affairs Medical Center - Gainesville
Gainesville, Florida, United States
Veterans Affairs Medical Center - Miami
Miami, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
Tampa, Florida, United States
Veterans Affairs Medical Center - Tampa (haley)
Tampa, Florida, United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, United States
Veterans Affairs Medical Center - Atlanta (decatur)
Decatur, Georgia, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, United States
Ccop - Central Illinois
Decatur, Illinois, United States
Ccop - Evanston
Evanston, Illinois, United States
Ccop - Illinois Oncology Research Association
Peoria, Illinois, United States
Swedish-American Regional Cancer Center
Rockford, Illinois, United States
Ccop - Carle Cancer Center
Urbana, Illinois, United States
Indiana University Cancer Center
Indianapolis, Indiana, United States
Veterans Affairs Medical Center - Indianapolis (roudebush)
Indianapolis, Indiana, United States
Ccop - Northern Indiana Cr Consortium
South Bend, Indiana, United States
Ccop - Cedar Rapids Oncology Project
Cedar Rapids, Iowa, United States
Ccop - Iowa Oncology Research Association
Des Moines, Iowa, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, United States
Burgess Health Center
Onawa, Iowa, United States
Ccop - Wichita
Wichita, Kansas, United States
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, United States
Ccop - Ochsner
New Orleans, Louisiana, United States
Mbccop - Lsu Health Sciences Center
New Orleans, Louisiana, United States

47 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cyclophosphamide →Doxorubicin →Prednisone →Rituximab →Vincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2003
Primary completion: —
Completion: 30 Jun 2006
Last update posted: 28 Jan 2014
Registered enrollment: —
Registry id: NCT00070447

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.