Clinical trialNCT00070564Active, not recruitingPhase 3Interventional

S0221 Adjuvant Doxorubicin, Cyclophosphamide, and Paclitaxel in Treating Patients With Breast Cancer

SponsorSWOG Cancer Research NetworkEnrollment3,294Breast Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them after surgery may kill any remaining tumor cells. It is not yet known which combination chemotherapy regimen is more effective in treating resected breast cancer. PURPOSE: This randomized phase III trial is comparing 2 different regimens of combination chemotherapy to see how well they work in treating patients who have undergone surgery for stage I, stage II, or stage III breast cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

George Thomas Budd, MD
The Cleveland Clinic
Study Chair
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Halle C Moore, MD
The Cleveland Clinic
Study Director
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

542 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Cancer Care Program at Thunder Bay Regional Health Sciences
Thunder Bay, Ontario, Canada
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, Canada

Puerto Rico

San Juan City Hospital
San Juan, Puerto Rico

United States

Regional Medical Center
Anniston, Alabama, United States
Uab Comprehensive Cancer Center
Birmingham, Alabama, United States
Providence Cancer Center at Providence Hospital
Mobile, Alabama, United States
Providence Cancer Center
Anchorage, Alaska, United States
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Alta Bates Summit Comprehensive Cancer Center
Berkeley, California, United States
Peninsula Medical Center
Burlingame, California, United States
East Bay Radiation Oncology Center
Castro Valley, California, United States
Valley Medical Oncology Consultants - Castro Valley
Castro Valley, California, United States
Valley Medical Oncology
Fremont, California, United States
California Cancer Center - Woodward Park Office
Fresno, California, United States
Todd Cancer Institute at Long Beach Memorial Medical Center
Long Beach, California, United States
Usc/norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States
Contra Costa Regional Medical Center
Martinez, California, United States
Tibotec Therapeutics - Division of Ortho Biotech Products, Lp
Marysville, California, United States
Memorial Medical Center
Modesto, California, United States
El Camino Hospital Cancer Center
Mountain View, California, United States
Sutter Health - Western Division Cancer Research Group
Novato, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Bay Area Breast Surgeons, Incorporated
Oakland, California, United States
Ccop - Bay Area Tumor Institute
Oakland, California, United States
Highland General Hospital
Oakland, California, United States
Larry G Strieff Md Medical Corporation
Oakland, California, United States
Tom K Lee, Incorporated
Oakland, California, United States
St. Joseph Hospital Regional Cancer Center - Orange
Orange, California, United States
Desert Regional Medical Center Comprehensive Cancer Center
Palm Springs, California, United States
Valley Medical Oncology Consultants - Pleasanton
Pleasanton, California, United States
Sutter Cancer Center at Roseville Medical Center
Roseville, California, United States
Sutter Cancer Center
Sacramento, California, United States
University of California Davis Cancer Center
Sacramento, California, United States
California Pacific Medical Center - California Campus
San Francisco, California, United States
Ucsf Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
Doctors Medical Center - San Pablo Campus
San Pablo, California, United States
Sutter Solano Medical Center
Vallejo, California, United States

502 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AC regimenCyclophosphamide →Doxorubicin →Paclitaxel →Pegfilgrastim →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2003
Primary completion: 31 Jan 2015
Completion: 31 Jan 2027
Last update posted: 31 Jul 2025
Registered enrollment: 3,294
Registry id: NCT00070564

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.