Clinical trialNCT00071721CompletedPhase 3Interventional

Valproate in Dementia (VALID)

SponsorAlzheimer's Disease Cooperative Study (ADCS)Enrollment313Alzheimer Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this trial is to demonstrate whether valproate therapy delays the emergence of agitation and/or psychosis in outpatients with probable Alzheimer's disease (AD) who have not experienced agitation and psychosis in their illness. A secondary aim is to determine whether valproate therapy delays the progression of cognitive and functional measures of the illness. This trial will also assess the tolerability and safety of low-dose, long-term valproate therapy. Valproate, an anticonvulsant drug, was selected because of its possible symptomatic efficacy for agitation in AD, known safety profile in numerous clinical populations, and in view of recent data supporting its neuroprotective potential in AD.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Pierre Tariot, MD
University of Rochester Medical Center, Departments of Psychiatry, Medicine, and Neurology, and the Center for Aging and Developmental Biology
Study DirectorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

46 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Sun Health Research Institute
Sun City, Arizona, United States
University of Arizona
Tucson, Arizona, United States
University of California, Irvine
Irvine, California, United States
University of California, Adrc, San Diego
La Jolla, California, United States
Va Healthcare System Long Beach
Long Beach, California, United States
University of California Adrc
Los Angeles, California, United States
University of California, la (olive View)
Los Angeles, California, United States
University of Southern California
Los Angeles, California, United States
Pacific Research Network
San Diego, California, United States
Stanford University, Va Aging Clinical Research Center
Stanford, California, United States
Yale University School of Medicine
New Haven, Connecticut, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
Howard University
Washington D.C., District of Columbia, United States
Mayo Clinic
Jacksonville, Florida, United States
Wein Center, Mount Sinai Medical Center
Miami, Florida, United States
Byrd Institute
Tampa, Florida, United States
University of South Florida
Tampa, Florida, United States
Premier Research Institute
West Palm Beach, Florida, United States
Emory University
Atlanta, Georgia, United States
Northwestern University
Chicago, Illinois, United States
Southern Illinois University
Springfield, Illinois, United States
Indiana University School of Medicine
Indianapolis, Indiana, United States
University of Kansas
Kansas City, Kansas, United States
Lahey Clinic, Research Neurology
Burlington, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Saint Mary'S Health Care
Grand Rapids, Michigan, United States
St. Louis University
St Louis, Missouri, United States
University of Nevada
Las Vegas, Nevada, United States
Albany Medical Center
Albany, New York, United States
Dent Neurologic Institute
Amherst, New York, United States
Columbia University
New York, New York, United States
New York University Medical Center
New York, New York, United States
Global Research and Consulting
Olean, New York, United States
University of Rochester
Rochester, New York, United States
Syracuse Va Medical Center
Syracuse, New York, United States
North East Ohio Health Services
Beachwood, Ohio, United States
Case Western Reserve University, University Hospitals of Cleveland
Cleveland, Ohio, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Brown University, Memorial Hospital of Rhode Island
Providence, Rhode Island, United States
Medical University of South Carolina-Columbia
Columbia, South Carolina, United States

6 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboValproate →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 2003
Primary completion: 28 Feb 2009
Completion: 31 Dec 2009
Last update posted: 25 Sept 2014
Registered enrollment: 313
Registry id: NCT00071721

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.