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Clinical trialNCT00074412CompletedPhase 3Interventional

Using Nevirapine to Prevent Mother-to-Child HIV Transmission During Breastfeeding

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment2,026HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The many benefits of breastfeeding are well documented. However, because of the risk of mother-to-child transmission (MTCT) of HIV from an HIV infected mother to her infant, there is considerable concern over the practice, especially in developing countries. The purpose of this study is to determine the safety and effectiveness of the anti-HIV drug nevirapine (NVP) in preventing MTCT of HIV in breastfeeding infants born to HIV infected women in South Africa, Tanzania, Uganda, and Zimbabwe.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Daya Moodley, MSc, PhD

    Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, University of Natal

    Study Chair
    clinicaltrials.gov ↗
  • Hoosen M. Coovadia, MD, MBBS

    Centre for HIV Networking (HIVAN), Nelson Mandela School of Medicine, University of Natal

    Study Chair
    clinicaltrials.gov ↗
  • Laura Guay, MD

    Johns Hopkins University

    Study Chair
    clinicaltrials.gov ↗
  • Wafaie Fawzi, MD, PhD

    Department of Nutrition, Harvard School of Public Health

    Study Chair
    clinicaltrials.gov ↗
  • Yvonne Maldonado, MD

    Stanford University

    Study Chair
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Africa
  • Caprisa Umlazi Crs

    Umlazi, KwaZulu-Natal, South Africa

Tanzania
  • Muhimbili University of Health and Allied Sciences (muhas) Crs

    Dar es Salaam, Tanzania

Uganda
  • Makerere University- Jhu Research Collaboration {mujhu Care Ltd} Crs

    Kampala, Mpigi, Uganda

Zimbabwe
  • Seke North Crs

    Chitungwiza, Zimbabwe

  • St Mary'S Crs

    Chitungwiza, Zimbabwe

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Nevirapine →Nevirapine placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jan 2007
Primary completion
30 Sept 2011
Completion
30 Nov 2011
Last update posted
16 Feb 2023
Registered enrollment
2,026
Registry id
NCT00074412
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.