Clinical trialNCT00076219CompletedPhase 3Interventional

Acute Renal Failure Trial Network (ATN) Study

SponsorUS Department of Veterans AffairsEnrollment1,124Acute Renal Failure

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi-center, prospective, randomized, parallel-group trial of an intensive strategy vs conventional strategy of renal replacement therapy for the treatment of acute renal failure secondary to acute tubular necrosis in critically ill patients. The primary hypothesis is that the intensive strategy will reduce 60-day all cause mortality by 10% compared to the conventional strategy - i.e.,a reduction from 55% in the conventional arm to 45% in the intensive arm. Secondary outcomes are 60-day in-hospital all-cause mortality, 1-year all cause mortality, and recovery of renal function by day 28. The study will recruit 1164 patients over a period of 3 years, 8 months and each patient will be actively followed for 60 days.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Paul M. Palevsky
VA Pittsburgh Health Care System
Study ChairKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

22 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Central Arkansas Vhs Eugene J. Towbin Healthcare Ctr, Little Rock
No. Little Rock, Arkansas, United States
Va Medical Center, San Francisco
San Francisco, California, United States
Va Greater Los Angeles Healthcare System, West la
West Los Angeles, California, United States
Va Eastern Colorado Health Care System, Denver
Denver, Colorado, United States
Va Connecticut Health Care System (west Haven)
West Haven, Connecticut, United States
Va Medical Center, Miami
Miami, Florida, United States
Va Medical Center, Augusta
Augusta, Georgia, United States
Richard Roudebush Va Medical Center, Indianapolis
Indianapolis, Indiana, United States
Va Maryland Health Care System, Baltimore
Baltimore, Maryland, United States
Va Medical Center, Jamaica Plain Campus
Boston, Massachusetts, United States
Va Ann Arbor Healthcare System
Ann Arbor, Michigan, United States
Va Medical Center, St Louis
St Louis, Missouri, United States
Va Western New York Healthcare System at Buffalo
Buffalo, New York, United States
Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States
Va Medical Center, Cleveland
Cleveland, Ohio, United States
Va Medical Center, Portland
Portland, Oregon, United States
Va Pittsburgh Health Care System
Pittsburgh, Pennsylvania, United States
Va Medical Center
Nashville, Tennessee, United States
Va North Texas Health Care System, Dallas
Dallas, Texas, United States
Michael E. Debakey Va Medical Center (152)
Houston, Texas, United States
Hunter Holmes Mcguire Va Medical Center
Richmond, Virginia, United States
Va Puget Sound Health Care System, Seattle
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 2003
Primary completion: 30 Sept 2007
Completion: 31 Jul 2008
Last update posted: 23 Aug 2013
Registered enrollment: 1,124
Registry id: NCT00076219

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.