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Clinical trialNCT00080106CompletedPhase 2Interventional

Effectiveness of and Immune Response to HIV Vaccination Followed by Treatment Interruption in HIV Infected Patients

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment114HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

HIV vaccines may help the immune systems of HIV infected patients better control the virus. The goal of this study is to determine whether patients on anti-HIV medications can stop taking those medications if they receive an HIV vaccine. While taking anti-HIV medications, participants will receive either an HIV vaccine or a placebo. Participants will then stop taking their anti-HIV medications and the study will compare the viral loads of participants who received the vaccine with the viral loads of participants who received the placebo. Primary study hypotheses: 1)The Week 12 and Week 16 post-ART interruption geometric mean HIV-1 RNA levels will be lower among participants who had received MRK Ad5 vaccine prior to ART interruption than among participants who received placebo; 2) the time averaged area under the curve of the log10 HIV-1 RNA copies/ml versus day function in the 16 week post-ART interruption step will be lower among participants who received the MRK Ad5 vaccine prior to ART interruption than among participants who receive placebo.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

28 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico
  • Puerto Rico-Aids Crs

    San Juan, Puerto Rico

United States
  • Ucla Care Center Crs

    Los Angeles, California, United States

  • Stanford Crs

    Palo Alto, California, United States

  • Univ. of California Davis Med. Ctr., Actu

    Sacramento, California, United States

  • Ucsd, Avrc Crs

    San Diego, California, United States

  • Ucsf Aids Crs

    San Francisco, California, United States

  • Univ. of Miami Aids Crs

    Miami, Florida, United States

  • Univ. of Hawaii at Manoa, Leahi Hosp.

    Honolulu, Hawaii, United States

  • Rush Univ. Med. Ctr. Actg Crs

    Chicago, Illinois, United States

  • Indiana Univ. School of Medicine, Infectious Disease Research Clinic

    Indianapolis, Indiana, United States

  • Ihv Baltimore Treatment Crs

    Baltimore, Maryland, United States

  • Beth Israel Deaconess Med. Ctr., Actg Crs

    Boston, Massachusetts, United States

  • Massachusetts General Hospital Actg Crs

    Boston, Massachusetts, United States

  • University of Minnesota, Actu

    Minneapolis, Minnesota, United States

  • Washington U Crs

    St Louis, Missouri, United States

  • Beth Israel Med. Ctr., Actu

    New York, New York, United States

  • Cornell Crs

    New York, New York, United States

  • Ny Univ. Hiv/aids Crs

    New York, New York, United States

  • Aids Care Crs

    Rochester, New York, United States

  • Univ. of Rochester Actg Crs

    Rochester, New York, United States

  • Unc Aids Crs

    Chapel Hill, North Carolina, United States

  • Case Crs

    Cleveland, Ohio, United States

  • Metrohealth Crs

    Cleveland, Ohio, United States

  • the Ohio State University Medical Center

    Columbus, Ohio, United States

  • Pitt Crs

    Pittsburgh, Pennsylvania, United States

  • the Miriam Hosp. Actg Crs

    Providence, Rhode Island, United States

  • Univ. of Texas Medical Branch, Actu

    Galveston, Texas, United States

  • University of Washington Aids Crs

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

MRK Ad5 HIV-1 gag vaccine
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Jun 2004
Primary completion
30 Sept 2007
Completion
31 May 2011
Last update posted
9 Nov 2021
Registered enrollment
114
Registry id
NCT00080106

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.