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Clinical trialNCT00080912CompletedInterventional

Single vs Multiple-Fraction Therapy in Treating Patients With Previously Irradiated Painful Bone Metastases

SponsorNCIC Clinical Trials GroupEnrollment850Metastatic CancerPain
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether single-fraction (single-dose) re-irradiation therapy is as effective as multiple-fraction (many small doses of radiation therapy) re-irradiation therapy in relieving bone pain caused by bone metastases. PURPOSE: This randomized phase III trial is studying single-dose radiation therapy to see if it works as well as multiple-dose radiation therapy in treating patients previously irradiated with painful bone metastases.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Tom Baker Cancer Centre

    Calgary, Alberta, Canada

  • the Vitalite Health Network - Dr. Leon Richard

    Moncton, New Brunswick, Canada

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, Canada

  • Cancer Centre of Southeastern Ontario at Kingston

    Kingston, Ontario, Canada

  • Grand River Regional Cancer Centre

    Kitchener, Ontario, Canada

  • Thunder Bay Regional Health Science Centre

    Thunder Bay, Ontario, Canada

  • Odette Cancer Centre

    Toronto, Ontario, Canada

  • Univ. Health Network-Princess Margaret Hospital

    Toronto, Ontario, Canada

  • Chum - Hopital Notre-Dame

    Montreal, Quebec, Canada

  • Mcgill University - Dept. Oncology

    Montreal, Quebec, Canada

  • Centre Hospitalier Universitaire de Sherbrooke

    Sherbrooke, Quebec, Canada

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, Canada

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Jan 2004
Primary completion
10 Apr 2013
Completion
16 Jan 2014
Last update posted
21 Aug 2023
Registered enrollment
850
Registry id
NCT00080912
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.