Clinical trialNCT00086190CompletedPhase 3Interventional

Study of Antidepressants in Parkinson's Disease

SponsorUniversity of RochesterEnrollment115DepressionParkinson Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to find out if two antidepressant medications, paroxetine and venlafaxine, can help control depression in Parkinson's disease, and if these medications affect the motor symptoms of Parkinson's disease such as tremor, stiffness, slowness, and balance.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Irene Richard, MD
University of Rochester
Principal Investigator
clinicaltrials.gov ↗
William McDonald, MD
Co-Principal Investigator--Emory University School of Medicine
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

London Health Sciences Centre, University Campus Room A10-325, 339 Windermere Road
London, Ontario, Canada
Hotel-Dieu Hospital-Chum
Montreal, Quebec, Canada

Puerto Rico

University of Puerto Rico
San Juan, Puerto Rico

United States

University of California San Francisco
San Francisco, California, United States
University of Florida
Gainesville, Florida, United States
University of Miami
Miami, Florida, United States
Emory University School of Medicine
Atlanta, Georgia, United States
University of Kentucky
Lexington, Kentucky, United States
Johns Hopkins University
Baltimore, Maryland, United States
University of Maryland
Baltimore, Maryland, United States
Beth Israel Deaconess Medical Center, Dept. of Neurology E/ks 430, 330 Brookline Avenue
Boston, Massachusetts, United States
Washington University School of Medicine
St Louis, Missouri, United States
University of Rochester
Rochester, New York, United States
Medical University of Ohio
Toledo, Ohio, United States
Oregon Health Sciences University
Portland, Oregon, United States
University of Tennessee-Memphis
Memphis, Tennessee, United States
Baylor College of Medicine, 6550 Fannin, Suite 1801
Houston, Texas, United States
University of Virginia
Charlottesville, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Paroxetine →Venlafaxine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 2005
Primary completion: 30 Nov 2009
Completion: 30 Nov 2009
Last update posted: 4 Jan 2013
Registered enrollment: 115
Registry id: NCT00086190

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.