Clinical trialNCT00088179CompletedPhase 3Interventional

Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)

SponsorAlexion Pharmaceuticals, Inc.Enrollment4,000Coronary Artery Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

During a heart bypass procedure, a substance called "complement" is activated by the body. This "complement activation" causes an inflammatory response that can lead to side affects such as chest pain, heart attacks, stroke, heart failure, or death. The purpose of this study is to find out if the study drug (pexelizumab), that blocks "complement activation," can reduce such side effects and be given safely to patients requiring the bypass procedure with the use of the heart-lung machine.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Edward Verrier, MD
University of Washington
Study Chair
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Peter X Adams, MD
Alexion Pharmaceuticals, Inc.
Study Director
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

188 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

France

Hopital Minjoz
Besançon, France
Hopital Du Bocage
Dijon, France
Hopital Albert Michallon
Grenoble, France
Hopital Europeen Georges Pompidou
Paris, France

Germany

Zentrum Fuer Herzchirurgie Der Frederick-Alexander-Universitaet
Erlangen, Germany

Netherlands

Leiden University Medical Center
Leiden, Netherlands

United States

Baptist Health Systems Montclair
Birmingham, Alabama, United States
Baptist Medical Center Princeton
Birmingham, Alabama, United States
Brookwood Medical Center
Birmingham, Alabama, United States
Medical Center East Hospital
Birmingham, Alabama, United States
University of Alabama at Birmingham Hospital
Birmingham, Alabama, United States
Thomas Hospital
Fairhope, Alabama, United States
Huntsville Hospital
Huntsville, Alabama, United States
Mobile Infirmary Medical Center
Mobile, Alabama, United States
Banner Good Samaritan Medical Center
Phoenix, Arizona, United States
Arizona Health Sciences Center
Tucson, Arizona, United States
Southern Arizona Veterans Affairs Health Care System
Tucson, Arizona, United States
University Medical Center
Tucson, Arizona, United States
Sparks Regional Medical Center
Fort Smith, Arkansas, United States
Baptist Medical Center
Little Rock, Arkansas, United States
Bakersfield Heart Hospital
Bakersfield, California, United States
Seaton Medical Center
Daly City, California, United States
Palomar Medical Center
Escondido, California, United States
Saddleback Memorial Medical Center
Laguna Hills, California, United States
Los Angeles County-University of Southern California Medical Center
Los Angeles, California, United States
St. Vincent Medical Center
Los Angeles, California, United States
University of Southern California University Hospital
Los Angeles, California, United States
Veterans Administration Greater Los Angeles Healthcare Sysytem
Los Angeles, California, United States
Tri City Medical Center
Oceanside, California, United States
University of California Irvine Medical Center
Orange, California, United States
Veterans Administration Palo Alto Healthcare System
Palo Alto, California, United States
Huntington Memorial Hospital
Pasadena, California, United States
Mercy General Hospital
Sacramento, California, United States
Sharp Memorial Hospital
San Diego, California, United States
Kaiser Permanente Medical Center
San Francisco, California, United States
Porter Adventist Hospital
Denver, Colorado, United States
Presbyterian St.Luke'S Medical Center
Denver, Colorado, United States
University of Colorado Health Sciences Center
Denver, Colorado, United States
St. Vincent'S Medical Center
Bridgeport, Connecticut, United States
Hospital of Saint Raphael
New Haven, Connecticut, United States

148 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pexelizumab in conjunction with CABG

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jul 2004
Primary completion: 31 Oct 2005
Completion: 31 Oct 2005
Last update posted: 22 Feb 2018
Registered enrollment: 4,000
Registry id: NCT00088179

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.