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Clinical trialNCT00098683CompletedPhase 2Interventional

Amifostine in Treating Young Patients With Newly Diagnosed De Novo Myelodysplastic Syndromes

SponsorChildren's Oncology GroupEnrollment10Myelodysplastic SyndromesMyelodysplastic/Myeloproliferative Neoplasms
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy, such as amifostine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. PURPOSE: This phase II trial is studying how well amifostine works in treating young patients with newly diagnosed de novo myelodysplastic syndromes.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

85 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Princess Margaret Hospital for Children

    Perth, Western Australia, Australia

Canada
  • University of Alberta Hospital

    Edmonton, Alberta, Canada

  • Children'S & Women'S Hospital of British Columbia

    Vancouver, British Columbia, Canada

  • Cancercare Manitoba

    Winnipeg, Manitoba, Canada

  • Iwk Health Centre

    Halifax, Nova Scotia, Canada

  • Mcmaster Children'S Hospital at Hamilton Health Sciences

    Hamilton, Ontario, Canada

  • Cancer Centre of Southeastern Ontario at Kingston General Hospital

    Kingston, Ontario, Canada

  • Hopital Sainte Justine

    Montreal, Quebec, Canada

  • Montreal Children'S Hospital at Mcgill University Health Center

    Montreal, Quebec, Canada

  • Centre Hospitalier Universitaire de Quebec

    Québec, Canada

Puerto Rico
  • San Jorge Children'S Hospital

    Santurce, Puerto Rico

United States
  • Phoenix Children'S Hospital

    Phoenix, Arizona, United States

  • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

    Little Rock, Arkansas, United States

  • Jonathan Jaques Children'S Cancer Center at Miller Children'S Hospital

    Long Beach, California, United States

  • Children'S Hospital Central California

    Madera, California, United States

  • Kaiser Permanente Medical Center - Oakland

    Sacramento, California, United States

  • Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center

    Farmington, Connecticut, United States

  • Lee Cancer Care of Lee Memorial Health System

    Fort Myers, Florida, United States

  • University of Florida Shands Cancer Center

    Gainesville, Florida, United States

  • Memorial Cancer Institute at Memorial Regional Hospital

    Hollywood, Florida, United States

  • Miami Children'S Hospital

    Miami, Florida, United States

  • Sacred Heart Cancer Center at Sacred Heart Hospital

    Pensacola, Florida, United States

  • All Children'S Hospital

    St. Petersburg, Florida, United States

  • St. Joseph'S Cancer Institute at St. Joseph'S Hospital

    Tampa, Florida, United States

  • Kaplan Cancer Center at St. Mary'S Medical Center

    West Palm Beach, Florida, United States

  • Winship Cancer Institute of Emory University

    Atlanta, Georgia, United States

  • Cancer Research Center of Hawaii

    Honolulu, Hawaii, United States

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, United States

  • Indiana University Cancer Center

    Indianapolis, Indiana, United States

  • St. Vincent Indianapolis Hospital

    Indianapolis, Indiana, United States

  • Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

    Kansas City, Kansas, United States

  • Kosair Children'S Hospital

    Louisville, Kentucky, United States

  • Ochsner Cancer Institute at Ochsner Clinic Foundation

    New Orleans, Louisiana, United States

  • Cancercare of Maine at Eastern Maine Medial Center

    Bangor, Maine, United States

  • Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

    Baltimore, Maryland, United States

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, United States

  • Hurley Medical Center

    Flint, Michigan, United States

  • Spectrum Health Hospital - Butterworth Campus

    Grand Rapids, Michigan, United States

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan, United States

  • Breslin Cancer Center at Ingham Regional Medical Center

    Lansing, Michigan, United States

45 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jan 2005
Primary completion
31 Oct 2007
Completion
31 Oct 2009
Last update posted
13 Feb 2014
Registered enrollment
10
Registry id
NCT00098683

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.