Clinical trialNCT00104988CompletedPhase 2Interventional

S0508: Thalidomide and Temozolomide in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery

SponsorSWOG Cancer Research NetworkEnrollment64Melanoma (Skin)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Thalidomide may stop the growth of melanoma by blocking blood flow to the tumor. It may also stimulate the immune system in different ways and stop tumor cells from growing. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving thalidomide together with temozolomide may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving thalidomide together with temozolomide works in treating patients with stage IV melanoma that cannot be removed by surgery.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Joseph I. Clark, MD
Loyola University
Study Chair
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Laura F. Hutchins, MD
University of Arkansas
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

132 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Regional Hospital Cancer Center
Anchorage, Alaska, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Eden Medical Center
Castro Valley, California, United States
North Bay Cancer Center
Fairfield, California, United States
Saint Rose Hospital
Hayward, California, United States
Usc/norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Ccop - Bay Area Tumor Institute
Oakland, California, United States
Highland General Hospital at St. George'S University School of Medicine
Oakland, California, United States
Valley Care Medical Center
Pleasanton, California, United States
Doctors Medical Center - San Pablo Campus
San Pablo, California, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola
Pensacola, Florida, United States
Northeast Georgia Medical Center
Gainesville, Georgia, United States
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, United States
St. Luke'S Mountain States Tumor Institute - Boise
Boise, Idaho, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States
Veterans Affairs Medical Center - Hines
Hines, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, United States
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, United States
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina, Kansas, United States
St. Francis Comprehensive Cancer Center
Topeka, Kansas, United States
Stormont-Vail Cancer Center
Topeka, Kansas, United States
Wesley Medical Center
Wichita, Kansas, United States
Christus Schumpert Cancer Treatment Center
Shreveport, Louisiana, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, United States
Mecosta County Medical Center
Big Rapids, Michigan, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, United States
Ccop - Grand Rapids
Grand Rapids, Michigan, United States
Lacks Cancer Center at Saint Mary'S Health Care
Grand Rapids, Michigan, United States
Metro Health Hospital
Grand Rapids, Michigan, United States
Spectrum Health Hospital - Butterworth Campus
Grand Rapids, Michigan, United States
Holland Community Hospital
Holland, Michigan, United States
Ted B. Wahby Cancer Center at Mount Clemens General Hospital
Mount Clemens, Michigan, United States
Hackley Hospital
Muskegon, Michigan, United States
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, United States
Munson Medical Center
Traverse City, Michigan, United States
Freeman Cancer Institute at Freeman Health System
Joplin, Missouri, United States
Ccop - Kansas City
Kansas City, Missouri, United States
Ccop - Cancer Research for the Ozarks
Springfield, Missouri, United States

92 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Temozolomide →Thalidomide →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 2005
Primary completion: 31 Jul 2007
Completion: 31 Aug 2009
Last update posted: 22 Aug 2012
Registered enrollment: 64
Registry id: NCT00104988

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.