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Clinical trialNCT00106964CompletedPhase 4Interventional

Comparison of Three Hepatitis B Vaccination Regimens in HIV-Positive Youth

SponsorUniversity of North Carolina, Chapel HillEnrollment371HIV InfectionHepatitis B
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Hepatitis B is a contagious virus that can damage a person's liver. It can be prevented by vaccination, but for many HIV-positive people, the vaccines do not help them achieve adequate protection against this virus. In an attempt to improve response to vaccination and achieve protection from hepatitis B, this trial will compare the immune system response to 3 hepatitis B vaccine regimens in HIV-positive adolescents 12 through 24 years of age.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

11 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Brazil
  • Federal University of Minas Gerais

    Belo Horizonte, Minas Gerais, Brazil

  • Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto/usp

    Ribeirão Preto, São Paulo, Brazil

  • Instituto de Infectologia Emilio Ribas

    São Paulo, São Paulo, Brazil

  • Hospital Dos Sevidores Do Estado

    Rio de Janeiro, Brazil

  • Ippmg-Ufrj

    Rio de Janeiro, Brazil

South Africa
  • Tygerberg Hospital

    Bellville, Cape Town, South Africa

  • Harriet Shezi Childrens Clinic Chris Hani Baragwanth Hospital

    Johannesburg, Gauteng, South Africa

United States
  • Childrens Hosp of Los Angeles

    Los Angeles, California, United States

  • University of California at San Francisco

    San Francisco, California, United States

  • Children'S Hosp Natinal Med Center

    Washington D.C., District of Columbia, United States

  • Tulane Med Center

    New Orleans, Louisiana, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Engerix-B 20 mcgEngerix-B 40 mcgTwinrix 720 EIA HAV Ag plus 20 mcg HBsAg
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jan 2004
Primary completion
31 Jan 2008
Completion
30 Jun 2009
Last update posted
29 Mar 2017
Registered enrollment
371
Registry id
NCT00106964

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.