Clinical trialNCT00107770CompletedPhase 1/PHASE2Interventional

Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis)

SponsorUS Department of Veterans AffairsEnrollment40Amyotrophic Lateral Sclerosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the study is to evaluate the safety of sodium phenylbutyrate (NaPB) treatment in subjects with amyotrophic lateral sclerosis (ALS) and the ability to take this medication without major side effects.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Robert Ferrante, PhD MSc
Edith Nourse Rogers Memorial Veterans Hospital, Bedford
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

10 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Va Medical Center, Iowa City
Iowa City, Iowa, United States
Va Medical Center, Lexington
Lexington, Kentucky, United States
Va Maryland Health Care System, Baltimore
Baltimore, Maryland, United States
Edith Nourse Rogers Memorial Veterans Hospital, Bedford
Bedford, Massachusetts, United States
Va Medical Center, Jamaica Plain Campus
Boston, Massachusetts, United States
Va Medical Center, Syracuse
Syracuse, New York, United States
Va Medical Center, Durham
Durham, North Carolina, United States
Va Medical Center, Cincinnati
Cincinnati, Ohio, United States
Va Pittsburgh Health Care System
Pittsburgh, Pennsylvania, United States
Michael E. Debakey Va Medical Center (152)
Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Phenylbutyrate →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2005
Primary completion: 30 Nov 2006
Completion: 30 Sept 2007
Last update posted: 11 Jan 2010
Registered enrollment: 40
Registry id: NCT00107770

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.